Drug candidate uses proteins to regulate genes in PD


Researchers are developing a drug candidate called HPPE that inhibits the Bach1 protein and activates the Nrf2 protein to reduce symptoms of Parkinson's disease, according to a study to be published in the Proceedings of the National Academy of Sciences. Mouse model tests showed HPPE could reduce symptoms when administered before the disease or after onset by switching on antioxidant genes and switching off genes that are linked to inflammation.

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