Animals are integral to quest for effective antibiotics | Host-directed therapy halts enteroviruses in mice, human cells | Multiple myeloma treatment shows promise in mice, monkeys
September 18, 2019
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Animals are integral to quest for effective antibiotics
Animals are integral to quest for effective antibiotics
(Sean Gallup/Getty Images)
Bacteria are evolving antimicrobial resistance faster than humans are developing new antibiotics, and researchers say animals are a crucial bridge between the Petri dish and human testing of new treatments, including a vaccine candidate for salmonellosis being developed by researchers led by Sophie Helaine. Bacteria respond differently in culture than in a living being, and it's important to test vaccines and antibiotics against a real-world infection, Helaine says.
Imperial College London (9/17) 
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Research Breakthroughs
Host-directed therapy halts enteroviruses in mice, human cells
Host-directed therapy halts enteroviruses in mice, human cells
(Pixabay)
Switching off the gene for methyltransferase SETD3 prevented viral replication in cells and completely protected mice and human lung cells from enteroviruses, and the mice with the gene switched off lived normal, healthy lives, researchers reported in Nature Microbiology. The researchers say the work is a step toward developing a drug that temporarily suppresses the protein to protect against rhinoviruses that cause the common cold as well as other enteroviruses that cause paralysis.
BBC (9/16) 
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Multiple myeloma treatment shows promise in mice, monkeys
Results from a preclinical study indicate that designing chimeric antigen receptor T cells to target the protein GPRC5D specifically could be a safe and effective strategy in treating multiple myeloma. Data from the study reported in the journal Science Translational Medicine showed the treatment was safely tested in mice and monkeys, which did not exhibit any clinical signs of toxicity.
Myeloma Research News (9/13) 
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Researchers adapt CAR T cells in search for heart therapy
A study in the journal Nature describes how scientists are developing chimeric antigen receptor T cells that can remove fibroblasts that cause cardiac fibrosis. Fibroblast activation protein was identified for the targeted cells, and tests in mice resulted in improved heart function and reduced fibrosis.
FierceBiotech (9/11) 
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Animal study pinpoints genetic variant for MRSA resistance
A specific DNMT3A variant that regulates interleukin-10 appears to help the human immune system clear methicillin-resistant Staphylococcus aureus, researchers reported in Proceedings of the National Academy of Sciences. Inhibiting methylation of the gene in animal models increased vulnerability to staph infections, and the finding could lead to targeted treatments.
CTV (Canada) (9/16) 
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Translational research grant unites veterinarians, physicians
The University of Wisconsin-Madison School of Veterinary Medicine received a $3 million, five-year grant from the NIH to fund One Health fellowships at 15 veterinary colleges, and one of the goals is to raise awareness of veterinary medicine among physicians. Early-career veterinary faculty will collaborate with other researchers studying similar diseases in humans such as skin allergies, osteoarthritis, cancer-related pain and epilepsy.
JAVMA News (9/11) 
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Other News
Animal Health
2 Northern white rhino embryos to be implanted in surrogates
2 Northern white rhino embryos to be implanted in surrogates
(Tony Karumba/AFP/Getty Images)
An international consortium of veterinarians and other scientists used in vitro fertilization to create two Northern white rhinoceros embryos that will be implanted in surrogate mothers. The subspecies' numbers have dwindled to two due to widespread poaching and war.
Quartz (tiered subscription model) (9/11) 
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Animal Rights Activity
Sustained animal rights campaign targets Texas A&M's effort to cure Duchenne MD
Researchers at Texas A&M University are under fire with a steady stream of protests, harassment and even sometimes death threats from animal rights activists for breeding dogs to study Duchenne muscular dystrophy, a severely debilitating, usually fatal disease that affects young boys. A similar disease occurs naturally in golden retrievers, and Texas A&M School of Veterinary Medicine and Biomedical Sciences Dean Eleanor Green says the need to use dogs for the study is unfortunate, but the animals "are loved from the minute they enter this world to the minute they leave it." Moreover, unaffected dogs used as controls are put up for adoption, including by families of children with DMD.
The Dallas Morning News (tiered subscription model) (9/12) 
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FBR News
FBR resource: Animal Research Perceptions vs. Reality
Animal rights groups mislead the public about animal research, but FBR is fighting back with facts. In this resource, highly respected neuro-oncologist and FBR Board Vice-Chair Dr. Henry S. Friedman refutes myths surrounding animal research with scientific evidence and sets the record straight on the reality and benefits of animal research. Check it out.
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The Foundation for Biomedical Research (FBR) is the nation’s oldest and largest non-profit dedicated to improving human and animal health by promoting public understanding and support for biomedical research. Our mission is to educate people about the essential role animal research plays in the quest for medical advancements, treatments and cures for both people and animals.
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