Physicians advocate treat-to-target approach for IBD | Celiac disease can put bone density at risk | Study shows how probiotics may help reduce inflammation
May 20, 2015
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From American College of Gastroenterology

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Physicians advocate treat-to-target approach for IBD
A treat-to-target approach for inflammatory bowel disease may lead to better doctor-patient relationships, Drs. David Rubin and Noa Krugliak Cleveland of the University of Chicago Inflammatory Bowel Disease Center wrote in The American Journal of Gastroenterology. They noted this approach may require additional education and some retraining for physicians and other members of a multidisciplinary IBD team. Read the abstract. Healio (free registration)/Gastroenterology (5/15)
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Guide to Healthy Living
Celiac disease can put bone density at risk
Celiac disease patients often have reduced bone density linked to nutrient malabsorption, hyperparathyroidism, autoimmune factors and inflammation, dietitians and medical experts said. Dietitians can help people tailor their diet to ensure they get enough calcium and other nutrients needed for bone health from foods they can tolerate, registered dietitian nutritionist Rachel Begun says. Today's Dietitian (5/2015)
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Study shows how probiotics may help reduce inflammation
Researchers at the University of Maryland have found that the probiotic Lactobacillus rhamnosus GG may help other gut microorganisms reduce inflammation. The study found that LGG can activate organisms that produce an anti-inflammatory fatty acid called butyrate. The Baltimore Sun (5/14)
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Constipation is often caused by dietary factors, physician says
Constipation is most often caused by dietary factors, such as eating too little fiber and not drinking enough water, says gastroenterologist Dr. Elizabeth Blaney. Prunes are commonly used for regularity, but Blaney says other high-fiber, lower-sugar foods, such as kiwi, aloe vera juice and beans, are also good options. CNN (5/18)
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Study ties peanut allergy to asthma in children
A study of more than 1,500 children with asthma says nearly 11% had a history of confirmed peanut allergy and about 20% had tested positive for peanut sensitivity. The findings, presented at the meeting of the American Thoracic Society, suggest children with asthma may benefit from a test for peanut sensitivity, lead author Dr. Robert Cohn said. HealthDay News (5/18)
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Paleo diet gains traction but dietitians still have concerns
The Paleo diet has found a niche in mainstream nutrition, and supporters say it helps them lose weight and improve their health. Dietitians Alison Ryan and Stacy DeRosa agree a Paleo diet may have some benefits but question whether eliminating entire food groups is a good idea and whether the average person can follow the plan without guidance. San Jose Mercury News (Calif.) (free registration) (5/13)
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Diagnosis & Treatment
Study assesses immune globulin for prevention of hepatitis C after transplant
An ongoing study found that high-dose hepatitis C immune globulin was associated with reduced recurrence of hepatitis C among liver transplant recipients receiving antiviral treatment, researchers reported at the International Liver Congress. Five percent of patients who received a 300 milligram/kilogram dose experienced reinfection, compared with 32% of patients who received a 200 mg/kg dose. The 200 mg/kg arm of the trial has been closed. Aidsmap (5/17)
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Use of "liquid biopsies" is becoming more common
Physicians increasingly are employing noninvasive blood tests to identify cancers, guide treatment and monitor responses to therapy. Several tests have reached the market and more are being developed. At the University of Texas M.D. Anderson Cancer Center, the tests are conducted for about 1 in 10 patients with metastatic colon cancer. The Associated Press (5/11)
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Clinical Trial Monitor
A selection of U.S. based clinical trials seeking participants
Efficacy and safety of anti-MAP therapy in adult Crohn's disease (MAPUS)
Arkansas, California, Connecticut, Florida, Georgia, Illinois, Iowa, Kansas, Louisiana, Maryland, Massachusetts, Michigan, Mississippi, Missouri, Montana, New Jersey, New York, Ohio, Tennessee, Texas, Virginia, Wisconsin, Canada, Israel.
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Safety and efficacy of MMX mesalamine/mesalazine in pediatric subjects with mild to moderate ulcerative colitis (PACE)
Florida, Georgia, Maryland, Massachusetts, Minnesota, Virginia, Canada, Hungary, Poland, Slovakia, United Kingdom.
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A multicenter, double-blind, randomized, placebo-controlled, parallel-group Phase 2 study to assess the efficacy, safety, and tolerability of Velusetrag for the treatment of diabetic or idiopathic gastroparesis
Arizona, Arkansas, California, Colorado, Florida, Kansas, Kentucky, Oklahoma, Oregon, Pennsylvania, Tennessee, Texas, Utah, Virginia.
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A study of Cologuard in an average risk population assessing a three-year test interval
California, Maryland, New York.
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Selumetinib and cyclosporine in treating patients with advanced solid tumors or advanced or metastatic colorectal cancer
California, Colorado, Missouri, New Jersey, North Carolina, Ohio, Pennsylvania, Texas.
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Did you know?
Differentiating food allergy and intolerance
"A true food allergy causes an immune system reaction that affects numerous organs in the body. It can cause a range of symptoms. In some cases, an allergic reaction to a food can be severe or life-threatening. In contrast, food intolerance symptoms are generally less serious and often limited to digestive problems. If you have a food intolerance, you may be able to eat small amounts of the offending food without trouble. ... Causes of food intolerance include: Absence of an enzyme needed to fully digest a food. ... Irritable bowel syndrome. ... Sensitivity to food additives. ... Recurring stress or psychological factors. ... Celiac disease." -- Mayo Clinic
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The Last Word
News and information from the American College of Gastroenterology
Gallstone disease: Are you at risk?
Gallstones are one of the most common gastrointestinal problems, especially for women. Women between the ages of 20 and 60 years are three times more likely to develop gallstones than men. Learn more about the symptoms and risk factors for developing gallstone disease.
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-- Mary Kay Ash,
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