Research team successfully edits rhesus monkey embryos | Aggressive cancer tumors in mice treated with new gene therapy | Immune systems of wild, lab mice differ
May 10, 2017
FBR Smartbrief
Top Story
Research team successfully edits rhesus monkey embryos
A study published in Human Molecular Genetics showed that rhesus monkey embryos can be edited using CRISPR-Cas9, and the research might improve some biomedical studies. "The closer we can approximate the human condition in the animal model, the better the chances of developing successful treatments as well as limiting risks that may be encountered in clinical trials," study leader Keith Latham said.
Futurity/Michigan State University (5/3) 
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Research Breakthroughs
Aggressive cancer tumors in mice treated with new gene therapy
Aggressive liver and prostate cancer tumors in mice shrank following a new CRISPR-based gene therapy, according to a study published in Nature Biotechnology. The therapy focused on cancer fusion genes, which are created when two distinct genes become joined.
The Scientist online (5/2) 
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Immune systems of wild, lab mice differ
A study comparing the immune systems of wild-caught house mice with those of mice raised in a laboratory revealed differences in 57 of 62 immunological measures and found that lab-raised mice have more sex-linked differences than their wild counterparts. The results, published in Nature Communications, highlight the need for caution in extrapolating lab results to wild animals, "but laboratory mouse models will continue to be hugely important in biological and biomedical research," researcher Mark Viney said.
The Scientist online (5/5) 
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Injected nanoparticle shrinks breast tumors in mice
Injected nanoparticle shrinks breast tumors in mice
(Justin Sullivan/Getty Images)
A nanoparticle injected into mice reduced HER2-positive breast tumors by 70% to 80% and provoked a strong, persistent immune response, according to a study published in Nature Nanotechnology. The nanoparticle, a multivalent bispecific nanobioconjugate engager, bears antibodies that target HER2 receptors and molecules that interact with the immune system.
University Herald (5/3) 
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Scientists develop bonelike implant that produces marrow
An implant developed by scientists at the University of California at San Diego resembles human bone and has allowed bone marrow cells to grow in tests involving mice, according to results published in the Proceedings of the National Academy of Sciences. The implant has an outer bonelike structure and an inner spongy matrix for donated stem cells.
New Scientist (free content) (5/8) 
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Other News
Animal Health
Petco and Blue Buffalo foundations deliver $11M blow to canine cancer
The Petco and Blue Buffalo foundations have devoted $11 million to the fight against canine cancer since the campaign began in 2010. The money helps families of pets with cancer, funds comparative oncology studies that try to find cancer treatments for malignancies that affect pets and people, and is allotted for other areas of cancer research.
Pet Product News (5/3) 
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UK veterinarians explore possible origins of Alabama rot
UK veterinarians are gathering this week to discuss Alabama rot, a deadly disease of unknown cause that was discovered in the US and has spread to the UK, where 100 dogs have been killed by the illness in the past four years. Veterinarian David Walker, an expert on Alabama rot, says the disease appears to occur mostly during the cooler months of November to May, suggesting environmental factors play a role.
BBC (5/10),  The Telegraph (London) (tiered subscription model) (5/9) 
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Policy News
PREDICT program aims to predict, prevent disease outbreaks
The collaborative USAID PREDICT program was developed to monitor, predict and prevent emerging diseases from turning into pandemics, and in the program's first five years, 2,500 people in 20 countries were trained to identify and effectively report zoonotic diseases, samples were collected from 56,340 wild animals, and 815 novel viruses were found. Monitoring diseases in animals can help prevent spillover events and transmission to people, and provides new information about the relationships among animals, environments and people, such as a recent study that found no significant benefit to human health from biodiversity.
Smithsonian online (5/5) 
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FBR News
Need cloud resources for your research?
The NIH is testing a new funding mechanism for its extramural research community. The NIH Commons Credits Pilot will advance biomedical research in big data and cloud computing. Help shape the future of cloud computing in biomedical research by registering now for the 2017 award cycle. Learn more.
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For 35 years, FBR has advanced biomedical research for the sake of both human and animal health. We can't do our job without your support. Please give what you can. Together we will continue to make a difference.
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The Foundation for Biomedical Research (FBR) is the nation’s oldest and largest non-profit dedicated to improving human and animal health by promoting public understanding and support for biomedical research. Our mission is to educate people about the essential role animal research plays in the quest for medical advancements, treatments and cures for both people and animals.
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