The gut microbiomes in two dog breeds are more similar than mouse or pig microbiomes to the bacterial populations in humans' guts, and changes in dietary carbohydrate and protein levels affected dog and human gut flora similarly. The findings, published in Microbiome, suggest not only that dogs could be good models for human nutrition studies, but also that human nutrition studies might be applicable to dogs.
An experimental therapy that cleared Zika virus from the blood of pregnant monkeys did not stop the virus from crossing into the amniotic fluid and infecting the fetus, researchers reported in Nature Communications. Researchers will now modify the antibodies so that they can cross the placental barrier and protect the fetus, said lead author Diogo Magnani.
RNA-infused nanoparticles delivered to the ears of deafened guinea pigs restored their hearing, according to findings published in Molecular Therapy. Hair cells inside the guinea pigs' ears showed signs of regrowth after being treated with the RNA.
Researchers found that acrolein accumulates in rat models of Parkinson's disease and is a key component in disease progression, but the acrolein-scavenging hypertension drug hydralazine alleviated symptoms in the animals. The findings, published in the journal Molecular and Cellular Neuroscience, support the development of acrolein-targeting drugs for Parkinson's disease, said researcher Jean-Christophe Rochet.
An experimental compound that binds to a protein found on the surface of sperm disrupts their motility, conferring lasting but reversible contraception when injected into male rhesus macaques, researchers reported in PLOS ONE. The researchers are developing an oral form of the compound.
Researchers at 11 university-based veterinary centers will compare an experimental immunotherapy for osteosarcoma against standard treatment in 80 dogs. The immunotherapy, which combines a molecule that cancer cells express with a modified live form of Listeria monocytogenes, extended survival in an 18-dog pilot study after primary tumor removal and four doses of carboplatin chemotherapy.
An international team of veterinarians and food safety scientists reported in Emerging Infectious Diseases that three dromedary camels in Algeria tested positive for a prion similar to the one that causes bovine spongiform encephalopathy, and they say immediate action should be taken to safeguard animal and human health. The prion could have come from infected feed, and researchers do not know whether it can be passed from animals to people who consume infected meat.
The US Court of Appeals for the 9th Circuit affirmed a lower court's ruling that a crested macaque has no legal right to photographs the monkey snapped of himself with photographer David John Slater's camera. The People for the Ethical Treatment of Animals had sued Slater and self-publishing company Blurb on the monkey's behalf, claiming that publishing and selling the photographs infringed on the monkey's rights under the Copyright Act.
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