Human monoclonal antibody cures Marburg, Ravn infections in monkeys | Learn more about the benefits of research involving nonhuman primates | Collaboration may yield treatments for cancers in humans, dogs
Treatment with a monoclonal antibody isolated from the blood of a woman who survived a Marburg virus infection cured Marburg as well as Ravn virus infections in monkeys, researchers reported in Science Translational Medicine. The NIH and the HHS Biomedical Advanced Research and Development Authority provided funding for the research, and scientists are now studying methods for producing large quantities of the antibody and testing it in humans.
Researchers at Children's Mercy Hospital in Kansas City, Mo., are working with animal health scientists to see whether a canine osteosarcoma drug works against glioblastoma in children. The researchers plan to apply for permission to conduct a Phase II clinical trial based on the drug's safety profile in dogs, and they are working with area universities to set up an electronic database for sharing data from animal and human trials.
Cricetulus griseus, a hamster endemic to China's northern deserts, has been important to medical research since the early 1900s because of the ease with which its cells -- particularly ovarian cells -- can be cultured and genetically modified. At least six top-selling biologic drugs, including the world's first biologic, are derived from lab-grown cell lines that originated in the species.
Biomedical researchers collect an assortment of samples in their search for cures, including cannibalistic cone snails, dirt, horseshoe crabs, feces and reptile venom. "We don't know what the role of one little fish or one little snake is unless we research every single thing on the planet," said Kristen Wiley, co-director of the Kentucky Reptile Zoo.
A newly developed transgenic mouse might help scientists predict whether a given influenza virus strain can evade the human immune protein MxA and thus has the potential to cause a global pandemic. The mice express human MxA instead of murine MxA and can distinguish between MxA-sensitive influenza virus strains and strains that can evade MxA, the scientists reported in the Journal of Experimental Medicine.
Researchers at the Queensland Brain Institute report in the journal Brain that they used ultrasound to deliver therapeutic antibodies to the brain, slowing the progression of Alzheimer's disease in mice. Ultrasound safely opened the blood-brain barrier enough to allow the delivery of an antibody that binds to tau proteins, and the researchers hope the technique can eventually be used to treat other neurological conditions, such as Parkinson's disease.
Clemson University veterinarian John Parrish examines mice, rats, sheep, horses and cows on any given day, and his background in comparative medicine reflects his interest in supporting human health, too. In his work with nonhuman primates, Parrish has seen firsthand the role of animals in research and the bonds caregivers form with research animals, whose well-being depends on patience and experience.
The FDA signed a cooperative research and development agreement with Wyss Institute spinoff Emulate to create a toxicity testing platform based on the company's organ-on-a-chip technology. The collaboration might eventually reduce the number of animals needed for preclinical testing.
The NIH is testing a new funding mechanism for its extramural research community. The NIH Commons Credits Pilot will advance biomedical research in big data and cloud computing. Help shape the future of cloud computing in biomedical research by registering now for the 2017 award cycle. Learn more.
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The Foundation for Biomedical Research (FBR) is the nation’s oldest and largest non-profit dedicated to improving human and animal health by promoting public understanding and support for biomedical research. Our mission is to educate people about the essential role animal research plays in the quest for medical advancements, treatments and cures for both people and animals.