The University of California at Irvine says an animal rights group made "false statements" about animals used in research at the institution, and FBR is supporting UC Irvine as it defends its researchers against what FBR says are "subversive, ... preposterous and dangerous" accusations. "They are attacking dedicated professionals to whom all Americans owe significant medical and scientific advancements. From basic pain medications and vaccines to life-saving procedures, animal research helps both humans and animals," says FBR President Matthew R. Bailey.
A live-attenuated Zika virus vaccine that protected mice and non-human primates might also kill human glioblastoma cells, according to research published in mBio. Zika virus targets fetal neural progenitor cells but is less harmful to differentiated, healthy brain cells, and the vaccine killed lab-grown glioblastoma cells as well as human glioblastoma cells transplanted into mouse brains.
Marburg virus persisted in the testes of crab-eating macaques, suggesting that Marburg and other filoviruses, such as Ebola, might also persist in human testes after the body clears the virus from other organs, researchers reported in Cell Host & Microbe. Marburg virus caused the breakdown of the blood-testes barrier that protects Sertoli cells, but the presence of the virus did not appear to affect sperm generation or reproductive function.
A skin patch of CRISPR-edited material grafted onto cocaine-addicted mice prevented them from overdosing on the drug, according to findings published in Nature Biomedical Engineering. Researchers used an augmented version of the enzyme butyrylcholinesterase, which breaks down cocaine, and expressed hope that their find could lead to a treatment for addiction.
The Argonaute 2 protein silences RNA and slows liver metabolism, impeding the organ's ability to process fat, and blocking AGO2 prevented obesity, diabetes and nonalcoholic fatty liver disease in mice fed a high-fat diet. The findings, published in Nature Communications, might have implications for treating chronic metabolic disorders in humans.
A chemically modified version of arylomycin pierces the wall of Gram-negative bacteria and binds to an enzyme in the inner membrane of multidrug-resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii obtained from patients, researchers reported in Nature. In mice, the new molecule prevented infection by six strains of four different Gram-negative bacteria, and it showed no signs of toxicity in mammalian cells.
A newly identified parvovirus with genomic traits similar to viruses that affect pigs, bats and rats causes a previously unexplained renal disease in middle-aged lab mice, researchers reported in Cell. The virus could cause variation in experimental outcomes, but it could also be useful in kidney research, says lead author Ben Roediger.
Canine adipose tissue and reproductive organs might be better sources than umbilical cord blood for obtaining mesenchymal stem cells for therapeutic use in dogs, according to a recent study. Canine umbilical cord blood can be obtained only by cesarean section and yields fewer MSCs than other sources, the researchers wrote.
FDA Commissioner Scott Gottlieb called for new funding mechanisms to support the battle against antimicrobial resistance, while also disclosing the agency's 2019 strategic plan that focuses on AMR. Gottlieb spoke of four crucial areas to address, including the development of products and surveillance tools for antimicrobial use and resistance, promotion of antimicrobial stewardship and support for research initiatives to discover alternative treatment approaches.
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The Foundation for Biomedical Research (FBR) is the nation’s oldest and largest non-profit dedicated to improving human and animal health by promoting public understanding and support for biomedical research. Our mission is to educate people about the essential role animal research plays in the quest for medical advancements, treatments and cures for both people and animals.