Ga-68 PSMA PET/MRI compared with mpMRI in prostate cancer analysis | Small study looks at antibiotic use before immunotherapy | Deep learning algorithm suggests risk factors for skin cancer
September 13, 2019
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Ga-68 PSMA PET/MRI compared with mpMRI in prostate cancer analysis
PET/MRI with gallium-68 PSMA yielded improved sensitivity but reduced specificity in determining both extracapsular extension and seminal vesicle invasion among individuals with intermediate to high risk prostate cancer, compared with multiparametric MRI, according to a Swiss study in the journal Radiology. The findings suggest similar performance between Ga-68 PSMA PET/MRI and mpMRI in local prostate cancer staging among those with intermediate or high risk disease, researchers wrote.
AuntMinnie (free registration) (9/12) 
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Clinical News & Research
Small study looks at antibiotic use before immunotherapy
People with cancer who took broad-spectrum antibiotics in the month before receiving immunotherapy drugs had significantly shorter survival, regardless of cancer type, compared with those who weren't given antibiotics, UK researchers reported in JAMA Oncology. However, the study was small and no effect was seen among those given antibiotics during immunotherapy.
The Guardian (London) (9/12) 
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Deep learning algorithm suggests risk factors for skin cancer
Researchers trained a deep learning convolutional neural network to predict skin cancer risk based on analysis of medical data and found that hypertension, chronic kidney disease and degenerative osteopathy increase the likelihood of skin cancer. The researchers also identified trazodone, acarbose, nonsteroidal anti-inflammatory drugs, systemic antifungal agents, statins and thiazide diuretics as potential risk factors, and researcher Christine Wang said the findings, in JAMA Dermatology, could enhance prevention or aid in early diagnoses.
United Press International (9/12) 
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Researchers adapt CAR T cells in search for heart therapy
A study in the journal Nature describes how scientists are developing chimeric antigen receptor T cells that can remove fibroblasts that cause cardiac fibrosis. Fibroblast activation protein was identified for the targeted cells, and tests in mice resulted in improved heart function and reduced fibrosis.
FierceBiotech (9/11) 
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Industry Report
Australian facility that makes Mo-99 is shut down for repairs
Lucas Heights, a nuclear medicine facility in Australia, closed last week until repairs can be made. The shutdown has raised concerns about a shortage of molybdenum-99, a radioisotope used to diagnose cancer.
The Guardian (London) (9/11) 
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News from the Field
How to improve recruitment in radiology residency programs
Radiology residency programs can better encourage medical students to enter the field by ensuring radiology's visibility as a career choice and increasing recruitment of underrepresented minorities, according to an editorial in Academic Radiology. Researchers also wrote that residency programs should make interventional radiology the center of their recruitment efforts, as well as consider more females in leadership roles.
Health Imaging online (9/12) 
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Health Policy
Debate spotlights policy divisions over health care
Debate spotlights policy divisions over health care
(Robyn Beck/AFP/Getty Images)
Health care again took center stage in Thursday's night Democratic debate, with former Vice President Joe Biden attacking Sens. Bernie Sanders, I-Vt., and Elizabeth Warren, D-Mass., over the cost of their Medicare for All proposal. Eight of the presidential hopefuls in Thursday's debate support a public option or some sort other policy framework that would maintain a substantial role for private health insurance.
National Public Radio (9/13) 
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Administration may switch focus from ACA replacement to court ruling
The Trump administration may be abandoning efforts to develop a replacement for the Affordable Care Act to focus instead on the potential fallout should a federal judge next month rule the law is unconstitutional, according to a White House staffer, congressional aides and activists. The White House said it has not stopped work on a plan to replace the ACA, but conservative groups said they have not been provided information on any potential overhaul.
The Washington Post (tiered subscription model) (9/12) 
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Advancing Health Care
Privacy concerns might impede use of EHR data for research
EHRs may be a treasure trove of data for health and medical research, but recent reports that de-identified patient data is not as anonymous as it seems have raised privacy concerns. Though de-identified data is not considered protected health information, HHS guidance says "there is a possibility that de-identified data could be linked back to the identity of the patient to which it corresponds."
Becker's Health IT & CIO Report (9/11) 
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Grab your 2019 Nuclear Medicine and Molecular Imaging Week gear and show your support for the profession!
Show your support for the profession and grab your 2019 Nuclear Medicine and Molecular Imaging Week merchandise today, including the popular "Nuclear Medicine...We're Scintillating" T-shirts first seen at the 2019 Annual Meeting in Anaheim! Supplies are limited! Order today.
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Submit an application for the 2020 SNMMI-TS Leadership Academy -- a unique opportunity to increase leadership skills and opportunities through a two-day course, fully funded by the Technologist Section. The technologist application deadline is September 15; the student application deadline is October 15. Apply today.
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The news summaries appearing in SNMMI SmartBrief are based on original information from multiple internet sources and are produced by SmartBrief, Inc., an independent e-mail newsletter publisher. The items above are not selected or reviewed by SNMMI prior to publication. Questions and comments may be directed to SmartBrief at
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