Clinical chemistry score more effective in identifying ACS risk | Study links SGLT1 genetic mutation to reduced diabetes risk | Study evaluates source of hospital-acquired bloodstream infections
October 16, 2018
AACC SmartBrief
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Clinical chemistry score more effective in identifying ACS risk
A clinical chemistry score that combined high-sensitivity cardiac troponin and glucose results with estimated glomerular filtration rate performed better in terms of sensitivity and specificity than high-sensitivity cardiac troponin results alone in stratifying risk among emergency room patients suspected of having acute coronary syndrome, a study found. Adopting the laboratory score could lead to better lab reporting and analytics needed for patient examination, researchers said.
Clinical Laboratory News (10/2018) 
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Science Briefs
Study links SGLT1 genetic mutation to reduced diabetes risk
A study in the Journal of the American College of Cardiology showed that individuals who had a genetic mutation in the gut that reduced SGLT1 function were at a lower risk of developing type 2 diabetes, as well as a lower risk of heart failure, obesity and mortality. Researchers evaluated data from 8,478 participants and found those with the genetic mutation also had a reduced glucose uptake, compared with those without the mutation.
Diabetes (UK) (10/10) 
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Study evaluates source of hospital-acquired bloodstream infections
A study in the journal Nature Medicine showed that bloodstream infections acquired by patients during a hospital stay can be traced to their own bodies, specifically to their large intestines. The findings were based on data from blood and stool samples of 30 patients who acquired bloodstream infections after undergoing a bone marrow transplant at Stanford Hospital between early 2015 and 2017.
United Press International (10/15) 
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Tech Briefs
Qiagen's next-gen GI panel debuts in Europe
Qiagen has released its next-generation QIAstat-Dx panel to Europe for use in one-step, fully integrated molecular analysis of gastrointestinal syndromes. The multiplex gastrointestinal panel enables detection of 24 gastrointestinal infections-causing viral, parasitic and bacterial pathogens.
StreetInsider (free content) (10/15) 
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Policy Briefs
CMS report: Bundled care initiative participants cut spending
Medicare payments were lower for 50 of 67 Bundled Payments for Care Improvement model clinical episode combinations, and 27 of those payment declines were statistically significant, according to a CMS report. Most of the savings came from reductions in post-acute care utilization, according to the report.
RevCycle Intelligence (10/10) 
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FDA issues draft guidance to enhance efficiency in drug development
The FDA on Monday unveiled two new draft guidance documents in an effort to improve the efficiency of the drug development process. The first document addresses the use of minimal residual disease as a biomarker for hematologic malignancy drug development in clinical trials, while the second focuses on regulatory framework pertinent to treatments, such as gene therapies, that address molecular changes that induce or contribute to disease progression.
BioCentury (10/15),  Seeking Alpha (10/15) 
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Practice Briefs
FDA approves red blood cell antigen typing test
The FDA has approved Progenika Biopharma's ID Core XT test for non-ABO red blood cell typing before transfusions. The test reports genotypes as final results.
Medscape (free registration) (10/12) 
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EU approves Hologic's real-time Bordetella test
European regulators have granted Hologic CE mark approval for the Panther Fusion Bordetella assay, a real-time PCR test that provides detection and differentiation of Bordetella pertussis and Bordetella parapertussis from nasopharynx samples.
FDAnews (10/15) 
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Business/Corporate Briefs
Myriad Genetics, Pfizer sign CDx commercialization plan
Myriad Genetics and Pfizer have reached a commercialization plan on promoting the use of Myriad's BRACAnalysis CDx test for determining which patients are suitable for treatment with Pfizer's talazoparib. The companies are expected to collaborate on a number of commercial activities while maintaining responsibility for their respective products.
Seeking Alpha (10/9) 
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