Statin use after pneumonia | Biomarkers for Alzheimer's disease | Teen use of medications nonmedically
November 15, 2012
AJM: From the publisher of The American Journal of Medicine
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Statin use after pneumonia
Although statin use is associated with decreased mortality after pneumonia, this effect weakens in important subgroups. Only a randomized controlled study can fully explore the link between statins and pneumonia mortality. The American Journal of Medicine (11/2012) Share: Email
Other than cervical cancer, it has become apparent that HPV causes vulvar and vaginal cancers in women, penile cancer in men, and anal cancer in both sexes. Furthermore, these viruses have been implicated in head and neck cancers in both men and women as well. American Journal of Medicine CME Program
Clinical Updates
Biomarkers for Alzheimer's disease
Young adults at genetic risk for autosomal dominant Alzheimer's disease have functional and structural MRI findings and Cerebrospinal fluid (CSF) and plasma biomarker findings consistent with A?1?42 overproduction. Although the extent to which the underlying brain changes are either neurodegenerative or developmental remain to be determined, this study shows the earliest known biomarker changes in cognitively normal people at genetic risk for autosomal dominant Alzheimer's disease. (Free registration required) The Lancet Neurology (11/2012) Share: Email
Teen use of medications nonmedically
In order to better inform intervention efforts, this study categorized a sample of high-school seniors according to their motivations for using prescription medications nonmedically. (Full-text access is time-limited.) Journal of Adolescent Health (11/2012) Share: Email
Diagnostic dilemmas in bacterial meningitis
Rapid diagnosis and treatment of acute community-acquired bacterial meningitis reduces mortality and neurological sequelae, but can be delayed by atypical presentation, assessment of lumbar puncture safety, and poor sensitivity of standard diagnostic microbiology. The authors review the diagnostic dilemmas, with a focus on the roles of clinical assessment and cerebrospinal fluid examination. (Free registration required.) The Lancet (11/10) Share: Email
Predictors for bradycardia requiring a pacemaker
This study concluded that among atrial fibrillation patients, heart failure and permanent atrial fibrillation each nearly triple the odds of developing bradycardia requiring a permanent pacemaker; while not statistically significant, our results suggest that women are more likely and African-Americans less likely to develop bradycardia requiring pacemaker implantation. The American Journal of Cardiology (11/1/2012) Share: Email
Effect of 17-OHP on preterm birth
Weekly 17-OHP does not reduce the frequency of preterm birth (PTB) in nulliparous women with a midtrimester CL <30 mm. American Journal of Obstetrics & Gynecology (11/2012) Share: Email
Chronic kidney disease mortality in the elderly
It is well established that in the general population chronic kidney disease (CKD) is associated with mortality, but little is reported about older nursing home residents with CKD's risk for all-cause mortality, cardiovascular-related or infection-related mortality, as well as risk for hospitalization. This Chinese study found that in older NH residents (mean age 86.0 + 7.6) with stage 3B and stage 4/5 CKD, all these associations were significantly higher and predicted higher risk of mortality. (Free abstract only.) Journal of the American Medical Directors Association (11/2012) Share: Email
Medical News
Type 2 diabetes control might not lower stroke risk
Patients with well-controlled type 2 diabetes showed lower blood pressure and cholesterol levels but had higher pulse wave velocity than patients in a control group, according to a study in Diabetes Care. Researchers said pulse wave velocity was associated with white matter lesions in diabetes patients and "may represent a clinically relevant parameter in the evaluation of cerebrovascular disease risk in type 2 diabetes." News (11/9) Share: Email
Risk of death higher with rheumatoid arthritis and depression
People who were diagnosed with rheumatoid arthritis as well as depression had double the risk of dying compared with those without depressive symptoms, according to a study presented at a meeting of the American College of Rheumatology. Depressed male patients were twice as likely to die compared with their female counterparts, researchers said. HealthDay News (11/10) Share: Email
Hip replacement patients at greater risk of stroke
Adults who underwent a total hip replacement had a higher risk of suffering an ischemic or hemorrhagic stroke two weeks after the procedure than those who didn't get the surgery, a Dutch study found. Researchers noted that antiplatelet therapy following discharge was associated with lower odds of ischemic stroke in the six weeks after the procedure. The findings were published in Stroke: Journal of the American Heart Association. MedPage Today (free registration) (11/11) Share: Email
Business Practice News
Hardship exemption deadline extended by CMS
CMS has extended its deadline for filing hardship exemptions to avoid Medicare payment penalties next year. CMS-designated groups and qualified professionals can claim the exemption on the CMS website until Jan. 31, 2013. Physicians who do not meet e-prescribing requirements could lose 1.5% of their Medicare payment rates next year without the exemption. Modern Medicine/Medical Economics (11/12) Share: Email
U.S. needs 52K additional primary care docs by 2025, study finds
The U.S. will need about 52,000 more primary care doctors by 2025 to accommodate population growth, shifting demographics and provisions in the Affordable Care Act, a study found. Physician office visits are expected to increase from 462 million in 2008 to 565 million in 2025, researchers reported in the Annals of Family Medicine. (11/13) Share: Email
Patient's Perspective
Study finds increased heart risk for relatives of cardiac death victims
Relatives of young people who died suddenly from heart conditions were more likely to develop heart disease than the general population, Danish researchers found. The risks were particularly high among first-degree relatives ages 34 and younger. The study appeared online in the European Heart Journal. MedPage Today (free registration) (11/13) Share: Email
Editor's Note
AJMPlus will not publish Thursday
In observance of Thanksgiving in the U.S., AJMPlus will not be published Thursday, Nov. 22. Share: Email
For the happiest life, rigorously plan your days, leave your nights open to chance."
-- Mignon McLaughlin,
American author and journalist Share: Email
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