Researchers using nuclear magnetic resonance spectroscopy have identified 20 metabolites that are linked to insulin resistance. The study, published in Diabetes, analyzed the metabolic profiles of 7,098 people. "Metabolic signatures extending beyond obesity and lipid abnormalities reflected the degree of insulin resistance evidenced in young, normoglycemic adults with sex-specific fingerprints," the researchers wrote.
Researchers who looked at hyperinsulinemic-euglycemic clamp data found true insulin resistance in 75% of participants with a glucose disposal rate of less than 5.6 mg/kg fat-free mass + 17.7 min. The study in Diabetes Care found the homeostasis model assessment of insulin resistance values showed an 89% sensitivity and 67% specificity in predicting insulin resistance in participants.
Type 2 diabetes patients who took insulin degludec showed lower rates of overall hypoglycemic episodes per year than their counterparts who received insulin glargine, according to two Phase III studies in The Lancet. Researchers also found that patients with type 1 or type 2 diabetes who were on degludec treatment had a 25% reduction in nocturnal hypoglycemia rates compared with those who took glargine.
Obesity prevalence among children younger than 6 in eastern Massachusetts was steady from 1999 to 2003, but significantly dropped from 2004 to 2008, according to a study in Pediatrics. Researchers assessed EMR data of almost 37,000 children from 1999 to 2008 and found that those on Medicaid had smaller declines in obesity prevalence compared with children covered by other health plans.
Reducing the amount of endoglin protein on the surface of stem cells curbs the production of fat cells, according to a study presented at the American Society for Biochemistry and Molecular Biology's annual meeting. Research on osteoporosis led to the discovery, which could have applications in treatments for obesity, researchers said.
The CMS has paid $4.5 billion in EHR incentives to 76,612 hospitals and doctors through March. In March, Medicare payments to eligible providers amounted to $339.9 million, while Medicaid incentives paid to professionals and hospitals for adopting, using and upgrading EHRs totaled $254.1 million.
The American College of Physicians published a position paper that calls for better funding for public health infrastructure such as medical informatics and staff training, as well as sufficient vaccine and drug supplies. The group said programs that address childhood obesity, smoking, substance abuse, mental illness and health disparities, among others, should receive funding priority.
Watson Pharmaceuticals introduced extended-release metformin hydrochloride, an authorized generic version of Shionogi's type 2 diabetes drug Fortamet. The debut coincides with the relaunch of Lupin's generic Fortamet.