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| April 26, 2012 |
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Study: Transfusion decisions vary widely in surgery
Doctors' decisions on when to transfuse can vary widely, and the association between transfusion and patient outcomes is inconsistent, according to a Johns Hopkins University study published in the journal Anesthesiology. Researchers evaluated the records of more than 48,000 patients, almost 3,000 of whom received blood transfusions during surgery, and found notable differences in hemoglobin levels at the time of transfusion. Doctors should be more aware of transfusion guidelines, and more education is needed, researchers said. Read about the AABB clinical practice guideline on red cell transfusion here. The Sun (Baltimore)/Picture of Health blog (4/25)
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Silicone "trap" could reduce blood volume needed for tests
Researchers have developed a device that uses a silicone compound to trap a single droplet of liquid, preventing evaporation or contamination. By preserving blood during transportation, the technique could allow single-droplet blood testing, researchers said. The findings were published in the Proceedings of the Royal Society A. ScienceMag.org/ScienceNow blog (4/24)
Microfluidic device extracts cancer cells from blood samples
Researchers from Harvard University and Children's Hospital Boston have developed a device for extracting circulating tumor cells from blood, and the device has potential applications in collecting stem cells. Tests on mice showed the microfluidic device can catch more than 90% of the cancerous cells and keep them intact for culturing, according to findings published in the journal Lab on a Chip. CNET/Cutting Edge blog (4/25)
Autologous cell therapy shows promise in anti-wrinkle trials
Injections of a patient's cultured collagen-producing fibroblast cells improved the appearance of nasolabial fold wrinkles in late-state clinical trials, according to research published in the journal Dermatologic Surgery. The Dermatologist online (4/20)
Biopharma is developing almost 300 vaccines
There are almost 300 preventive and therapeutic vaccines under development by biotech firms, according to the Pharmaceutical Research and Manufacturers of America. Vaccines in clinical studies or under FDA review include 170 for infectious diseases and 102 for cancer. PharmaTimes (U.K.) (4/24)
Ultrasound alone may rule out deep vein thrombosis in pregnancy
A study published online in the British Medical Journal showed a single ultrasound test could rule out deep vein thrombosis during and after pregnancy. Researchers followed 210 women who received a complete compression ultrasonography exam. Only two of 177 women who tested negative developed DVT during the follow-up period. Medscape (free registration) (4/24)
Small health groups remain slow to adopt EHRs, studies show
A pair of studies in the journal Health Affairs indicated that small, rural hospitals and physician practices continue to lag large, urban facilities in implementing EHRs. The researchers recommended the federal government continue to provide incentives and assistance to smaller practices and step up efforts to help slow adopters deploy EHRs. Modern Healthcare (subscription required) (4/25)
FDA user fee reauthorization faces obstacles
Differences between House and Senate versions of bills reauthorizing the FDA Prescription Drug User Fee Act could delay the bill's progress. Differences include terms for exclusivity periods for new antibiotics, the FDA's mission and guidelines for how the agency determines devices' risks. Politico (Washington, D.C.) (4/25)
Transfusion journal highlights use of platelets to reverse antiplatelet drug effects
An article published in the April issue of Transfusion focuses on the transfusion of platelets to reverse antiplatelet drug effects. The article describes the mechanism of action of new antiplatelet agents and assesses treatment approaches to reverse their action with platelet transfusion or other pharmacologic agents. Continuing medical education credits are being offered for reading and successfully completing a test on the article. Read the abstract or visit the CME website.
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