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March 27, 2013
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Research transforming the study of diabetes and obesity

  Top Story 
  • Research shows how human microbiome changes affect obesity
    Two recent studies linked early use of antibiotics to obesity through possible microbiome changes while a third showed how bariatric surgery alters gut microbiota composition for beneficial outcomes. "We are just beginning to appreciate how integral the gut microbiome is to human health and disease," said New York University professor Dr. Ilseung Cho, lead investigator for one of the studies on antibiotics. General Surgery News (free registration) (3/2013) LinkedInFacebookTwitterEmail this Story
  Science & Research 
  • Experts link 25K U.S. deaths to sugar-sweetened drinks
    Approximately 180,000 deaths worldwide, including 25,000 deaths in the U.S., in 2010 were associated with consumption of sugar-sweetened beverages, according to a study presented at the American Heart Association meeting. The findings do not prove a causal effect, but rather link a high intake of sugary drinks to deaths due to heart disease, diabetes and cancer, researchers said. U.S. News & World Report/HealthDay News (3/19) LinkedInFacebookTwitterEmail this Story
  • DNA methylation may curb diabetes risk, study finds
    Swedish researchers found modifying genetic functions through DNA methylation appeared to influence insulin-producing cells to regulate the amount of insulin they contain and release into the bloodstream. "This means that we gain a tool to influence the function of the risk genes, improve insulin release and thereby reduce the risk of diabetes," researcher Charlotte Ling said. The findings were published in Diabetologia. (India)/Asian News International (3/20) LinkedInFacebookTwitterEmail this Story
  • Experts link gene mutation to type 1 diabetes onset
    A mutation in the SIRT1 gene served as a common marker of autoimmune disease in a family with four members who had type 1 diabetes, Swiss researchers wrote in Cell Metabolism. Data from animal studies also showed deactivating the gene triggered pancreatic islet destruction, predisposing lab mice to a higher risk of diabetes. (U.K.) (3/6) LinkedInFacebookTwitterEmail this Story
  • Exercise may lower cardiac mortality risk in diabetes
    Norwegian researchers found adults with diabetes were two to three times as likely as those without the condition to die from cardiovascular disease. However, diabetes patients who reported one to two hours of weekly exercise had a similar risk as inactive adults who didn't have diabetes, researchers wrote in Diabetes Care. News (3/15) LinkedInFacebookTwitterEmail this Story
  • Childhood carbohydrate diet may lead to lifelong obesity
    Animal research seems to indicate that a carbohydrate diet very early in life may lead to weight gain that cannot be reversed later through dieting. "Our hypothesis has been that the introduction of baby foods too early in life increases carbohydrate intake, thereby boosting insulin secretion and causing metabolic programming that ... predisposes the child to obesity," said Dr. Mulchand Patel. The study was published in the American Journal of Physiology: Endocrinology and Metabolism. (3/19) LinkedInFacebookTwitterEmail this Story
  Products & Innovation 
  • Skin implant can monitor, transmit glucose levels
    Swiss researchers have developed a small, implantable device that can analyze chemical and protein levels and transmit wireless updates. A patch located on top of the skin powers the implant, which can monitor glucose levels in patients with diabetes, warn of impending heart attacks and help determine optimal chemotherapy doses. Research on the device was to be presented at the Design, Automation, and Test in Europe conference. Medical News Today (3/20) LinkedInFacebookTwitterEmail this Story
  • Diet drug shows efficacy in lowering calorie intake
    British researchers found that a drug that combines glucagon and glucagon-like peptide 1 hormones helped participants consume 200 fewer calories from a heavy meal. The drug, currently available only as an infusion, may be taken as a once-weekly injection and may be ready for general use by 2020, researchers said. The findings were to be presented at the Society for Endocrinology meeting. The Daily Mail (London) (3/18) LinkedInFacebookTwitterEmail this Story
  Trends & Technology 
  TRI News 
  • Poll: Recent studies have shown a potential link between disturbances to the gut microbiome and obesity. In which areas do you think researchers should primarily focus their efforts to learn more?
Potential effects of bariatric surgery on the microbiome
The use of antibiotics in infants and a potential correlation with developing obesity later in life
The effects of disturbances to the microbiome in other diseases compared with those in obesity
All of these areas are equally important for researchers to investigate

  • Poll: There are approximately 25 metabolic disorders that can mask as typical T2D but often go misdiagnosed and undetected. Considering tomorrow is International Rare Disease Day, what is the most important way to spur therapeutic advancements for these rare metabolic disorders?
    Increase funding to advance understanding of genetic underpinnings of T2D and related metabolic disorders  33.33%
    Create databases to capture genetic information for T2D patients to detect patient sub-populations  33.33%
    Promote early detection by raising awareness of signs and symptoms of known disorders such as LADA  16.67%
    Enhance collaboration between the academic community and industry  16.67%
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You may have to fight a battle more than once to win it."
--Margaret Thatcher,
British prime minister

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