Most Clicked SNMMI SmartBrief Stories

1. Tc-99m agents show promise in prostate cancer imaging

SNMMI SmartBrief | Nov 20, 2014

New technetium-99m agents MIP-1404 and MIP-1405 could be used with SPECT and planar imaging to detect prostate-specific membrane antigen in bone, lymphatic and soft tissues in patients with prostate cancer, according to a study in the Journal of Nuclear Medicine. MIP-1404's slower renal clearance may be useful for pelvic imaging, while MIP-1405 could be used in imaging other regions. MIP-1404's minimal urinary excretion in healthy subjects suggests it could be used in early detection of prostate cancer. (11/19)

2. F-18 mefway shows potential in neuroimaging

SNMMI SmartBrief | Nov 17, 2014

A study in the Journal of Nuclear Medicine that involved two men and four women imaged using F-18 mefway PET and MR suggests this new serotonin-1A receptor ligand could be useful for psychiatric and neurodegenerative diagnostics. The agent is relatively simple to synthesize, has a high signal-to-noise ratio and has minimal bone signal, according to the authors. (11/14)

3. Scientists produce medical isotopes using X-rays

SNMMI SmartBrief | Nov 17, 2014

A team of scientists has generated medical isotopes using X-rays, a breakthrough that could help ease worries about supplies of medical isotopes used for diagnostic purposes. Two or three facilities like the one led by Mark de Jong that uses the Canadian Light Source synchrotron could meet all of Canada's need for the isotopes, de Jong says. Toronto Star, The (11/14)

4. NorthStar receives another federal grant for isotope technology

SNMMI SmartBrief | Nov 18, 2014

NorthStar has received an additional $5.2 million from the Energy Department's National Nuclear Security Administration to support the development and commercialization of the company's technology for producing molybdenum-99 without the use of highly enriched uranium. When approved by the FDA, NorthStar's neutron capture process will help establish reliable domestic production of Mo-99, the company said. (11/17)

5. PET study links periodontal disease with amyloid accumulation

SNMMI SmartBrief | Nov 21, 2014

Periodontal disease in cognitively normal and otherwise healthy older people is associated with amyloid accumulation, according to a study in the journal Neurobiology of Aging that evaluated 38 subjects with oral health exams and C-11 PIB-PET and MR. Of the subjects, 13 had extensive periodontal disease, and high levels of clinical attachment loss -- a measure of oral disease progression -- correlated with C-11 PIB uptake in the brain. (11/19)

6. Scientists ID new therapeutic target for Alzheimer's disease

SNMMI SmartBrief | Nov 19, 2014

Blocking a key receptor in brain cells that is used by oxygen-free radicals could prevent Alzheimer's disease, according to a study in the journal Neurobiology of Aging. Researchers found that oxygen-free radicals produced from oxidative stress bind to a thromboxane receptor, or TP, a protein receptor in the brain that sends signals to neuronal cells to increase the production of phosphorylated tau or amyloid beta. Researchers think compounds that work against TP could help improve therapy for AD. (11/18)

7. FDG-PET shows potential in diagnosing prosthetic valve endocarditis

SNMMI SmartBrief | Nov 18, 2014

FDG-PET showed 93% sensitivity and 94% predictive value compared with 63% sensitivity of leukocyte scintigraphy in detecting infected prosthetic heart valves, according to a study in the Journal of Nuclear Medicine that involved 39 patients with suspected infective endocarditis and inconclusive echocardiography results. Although FDG-PET showed high sensitivity, leukocyte scintigraphy had 100% specificity, which suggests it could still be used to verify unclear FDG-PET scans and for other kinds of inflammation. (11/17)

8. Toshiba to launch updated CT and new PET/CT systems

SNMMI SmartBrief | Nov 18, 2014

Toshiba has announced updates to its Aquilion CT scanners and the release of its Celesteion PET/CT system. The Aquilion system will feature dynamic clinical applications that use wide detector CT technology. The Celesteion PET/CT system will include a larger bore, wide field-of-view with dose reduction and rapid imaging features. Diagnostic Imaging (11/17)

9. European Commission approves Lymphoseek for some cancers

SNMMI SmartBrief | Nov 21, 2014

The European Commission has approved Navidea Biopharmaceuticals' Lymphoseek for detecting sentinel lymph nodes in primary breast cancer, localized squamous cell carcinoma and melanoma. Lymphoseek has also been approved by the FDA for sentinel lymph node mapping in all solid tumors. (11/20)

10. Overuse of anti-clotting drugs may increase dementia risk

SNMMI SmartBrief | Nov 17, 2014

A study presented at a meeting of the American Heart Association found that patients with atrial fibrillation who showed signs of overtreatment with anti-clotting drugs faced more than twice the risk of developing dementia. The results "suggest that microbleeds may result in chronic brain injury and be another factor that contributes to the association of atrial fibrillation with dementia," cardiologist Dr. Gregg Fonarow observed. HealthDay News (11/17)

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