Most Clicked AABB SmartBrief Stories


1. AABB submits comments to FDA on bacterial detection testing draft guidance

AABB SmartBrief | Mar 20, 2015

AABB has submitted comments to FDA on its draft guidance, "Bacterial Detection Testing by Blood and Blood Collection Establishments and Transfusion Services to Enhance the Safety and Availability of Platelets for Transfusion." Based on a review of the FDA's recommendations and with input from the Transfusion Transmitted Diseases Committee and its Bacterial Contamination Work Group, AABB recommends that FDA mandate the implementation of one of two enhanced safety strategies: bacterial testing or pathogen reduction with FDA-approved or cleared technologies. In addition, the association recommends that FDA clearly delineate the pathway to licensing 7-day platelets through increased bacterial testing or pathogen reduction with FDA-approved or cleared technologies. AABB believes that simplifying the recommended testing process would facilitate its successful implementation by blood centers and transfusion services. To that end, AABB recommends confining secondary testing to a single, one-time event which would be sufficient to extend the platelet product expiration date through day seven. In addition, the comments include recommendations and requests for clarification regarding a number of specific recommendations in the guidance. Blank (03/19)


2. Study projects increase in chronic brain bleeding in U.S.

AABB SmartBrief | Mar 23, 2015

Researchers analyzed data on U.S. veterans as well as registries from Finland and Japan and projected an annual rate of 60,000 U.S. cases of chronic subdural hematoma by 2030. The findings were published in the Journal of Neurosurgery. Medical News Today (03/21)


3. Laboratory study converts leukemia cells into healthy macrophages

AABB SmartBrief | Mar 19, 2015

A study in the Proceedings of the National Academy of Sciences describes the conversion of Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia cancer cells into immune cells. Cancerous precursor cells were exposed to transcription factors to prompt differentiation as macrophages, according to researchers from Stanford University. Medical News Today (03/19)


4. Scientists identify leukemia mutations linked to relapse

AABB SmartBrief | Mar 24, 2015

A 20-patient whole-exome sequencing study in the journal Nature Communications found that minor but distinctive mutations of acute lymphoblastic leukemia cells were associated with relapse. Seven genes were identified where mutations were likely in cases of relapse: CREBBP, IKZF1, NRAS, NT5C2, TP53, USH2A and WHSC1. GenomeWeb Daily News (free registration) (03/20)


5. Study links viral mutations with false-negative tests for hepatitis B

AABB SmartBrief | Mar 23, 2015

Mutations allow the hepatitis B virus to persist undetected by the immune system as well as diagnostic tests, according to a study in the journal PLOS One. Researchers analyzed viral genes from patients with occult hepatitis B infections and identified variations associated with reduced hepatitis B surface antigen secretion as well as with hepatitis B surface antigen truncation. MedPage Today (free registration) (03/21)


6. Anti-clot device implanted in atrial fibrillation patients

AABB SmartBrief | Mar 24, 2015

Surgeons have begun implanting Boston Scientific's Watchman left atrial appendage closure device in patients with atrial fibrillation following its approval by the FDA. The device is meant to keep blood clots out of the bloodstream. Los Angeles Times (tiered subscription model) (03/23)


7. Platelets produced in silk model of human bone marrow

AABB SmartBrief | Mar 23, 2015

Researchers at the Tufts University School of Engineering and the University of Pavia in Italy have developed a three-dimensional silk, collagen and fibronectin model of human bone marrow. Cultured megakaryocytes developed platelets in the matrix. Newsweek (03/21)


8. Imaging study finds brain swelling in fatal pediatric malaria cases

AABB SmartBrief | Mar 20, 2015

A study in The New England Journal of Medicine found that brain swelling was more common among children who died from cerebral malaria than in those who survived the condition. The study involved 168 pediatric patients who received magnetic resonance imaging scans. New York Times (tiered subscription model), The (03/20)


9. Researchers seek predictive blood test for osteoarthritis

AABB SmartBrief | Mar 24, 2015

A study in the journal Scientific Reports found that levels of citrullinated proteins were elevated in patients with early osteoarthritis and early rheumatoid arthritis. The study team is developing a combined test for citrullinated proteins, antibodies to citrullinated proteins and hydroxyproline as a predictive diagnostic for osteoarthritis. Medical News Today (03/23)


10. Gauss Surgical's blood-loss monitoring application is cleared by FDA

AABB SmartBrief | Mar 19, 2015

Gauss Surgical has received FDA clearance for its Triton Canister iPad application for the tracking of blood lost to surgical suction containers. The cloud-based technology analyzes images to estimate the amount of lost blood, accounting for factors such as differing levels of light and the presence of saline solution. MedGadget.com (03/18)




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