Most Clicked AABB SmartBrief Stories

1. AABB posts transcript from "Ask the FDA and CMS/CLIA" session

AABB SmartBrief | Jan 23, 2015

A transcript from the "Ask the FDA and CMS/CLIA" session that took place during the 2014 AABB Annual Meeting is now available online. Experts responded to questions about technical consultant qualifications under CLIA moderate/high complexity testing requirements, competency assessments and proficiency testing requirements. In addition, panelists addressed questions related to platelet dating and bacterial testing of platelets; clarification of syphilis results notification recommendations from the 2014 guidance; processing changes made by cord blood manufacturers that may require a supplement; current considerations for Hematopoietic Progenitor Cell Apheresis products; medical device data systems; laboratory-developed tests; and FDA plans for interventions to prevent transfusion transmission of the chikungunya, dengue and Ebola viruses. Blank (01/23)

2. Sepsis screening tool associated with reduced mortality in study

AABB SmartBrief | Jan 26, 2015

A screening score based on white blood cell counts and vital signs can be used to identify cases of sepsis and reduce mortality among trauma patients, according to a study presented at a meeting of the Society of Critical Care Medicine. The tool generates a score based on twice-daily assessments of leukocytes, body temperature and respiratory and heart rates. In the 1,637-patient study at the Texas Trauma Institute, the sepsis score had a sensitivity of 92.5% and a specificity of 97.4%, and its use was associated with a reduction in 30-day mortality in intensive care. Medscape (free registration) (01/23)

3. Fecal transplant treats Crohn's disease, ulcerative colitis in animal studies

AABB SmartBrief | Jan 23, 2015

University of Utah researchers have found that fecal transplants appear to reverse autoimmune diseases of the bowel such as Crohn's disease and ulcerative colitis in mice. The transplant of fecal material in mice via a tube into the stomach restored the balance of intestinal flora and normalized the intestines' function. The study appears in the journal Cell Host & Microbe. Voice of America (01/22)

4. Normal D-dimer levels after anticoagulation linked with reduced risk of thromboembolism

AABB SmartBrief | Jan 23, 2015

Women who achieved normal D-dimer levels after anticoagulant treatment for a first venous thromboembolism were at lower risk for recurrence, according to a study in the Annals of Internal Medicine. The study of 410 patients found support for stopping anticoagulation therapy in women but not men based on D-dimer levels. Healio (free registration) (01/21)

5. Blood test diagnoses heart attacks in women

AABB SmartBrief | Jan 22, 2015

A new blood test is twice as effective at diagnosing heart attacks in women than a test currently used in the U.K., according to a 1,126-patient study in The BMJ. The test detects very small levels of the heart attack biomarker troponin. A 26,000-patient study is being planned. BBC (01/21) PharmaTimes (U.K.) (01/21)

6. Study examines oral anticoagulant therapy for antiphospholipid syndrome

AABB SmartBrief | Jan 22, 2015

The use of new oral direct thrombin and factor Xa inhibitors such as dabigatran and rivaroxaban was associated with an 86.6% event-free survival rate after 12 months for patients with antiphospholipid syndrome, according to a study presented at a meeting of the American College of Rheumatology. The 24-patient, multi-center study supports the use of oral direct inhibitors as an alternative therapy, according to researchers. Healio (free registration) (01/21)

7. Analysis examines pneumonia risk after heart surgery transfusions

AABB SmartBrief | Jan 28, 2015

An analysis of data involving more than 16,000 patients who had bypass surgery from 2011 to 2013 found that those who had red blood cell transfusions developed pneumonia at higher rates. The risk of pneumonia was twice as high for patients who received one or two units of blood compared with patients who did not receive a transfusion. Transfusions of six units or more were associated with a 14-fold increase in risk. The findings were reported at a meeting of the Society of Thoracic Surgeons. HealthDay News (01/27)

8. Stem cell-derived myocardial tissue is tested in preclinical study

AABB SmartBrief | Jan 27, 2015

Transplanted myocardial cells derived from induced pluripotent stem cells were incorporated into the hearts of rats in a study of myocardial infarction, according to researchers at Osaka University. The study team used X-ray imaging from Japan's SPring-8 synchrotron radiation facility to confirm that the implanted cells had integrated into the heart tissue. Yahoo (01/27)

9. January issue of AABB News highlights PBM around the world

AABB SmartBrief | Jan 26, 2015

While they may take different names, patient blood management principles are used by professionals worldwide. The January issue features snapshots of activities in six countries with established PBM programs -- Australia, Canada, Germany, the Netherlands, Spain and the United Kingdom. In addition, the article highlights PBM efforts in the United States as well as AABB's new director of patient blood management. Blank (01/26)

10. Burn clinic to test use of marrow-derived stem cells

AABB SmartBrief | Jan 26, 2015

Researchers at the University of Miami are conducting a study of the use of stem cells for the treatment of severe burns. Mesenchymal stem cells will be collected from patients' bone marrow and injected into the damaged skin every two weeks. Miami Herald (tiered subscription model), The (01/25) Inquisitr, The (01/25)

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