Most Clicked AABB SmartBrief Stories

1. Sepsis screening tool associated with reduced mortality in study

AABB SmartBrief | Jan 26, 2015

A screening score based on white blood cell counts and vital signs can be used to identify cases of sepsis and reduce mortality among trauma patients, according to a study presented at a meeting of the Society of Critical Care Medicine. The tool generates a score based on twice-daily assessments of leukocytes, body temperature and respiratory and heart rates. In the 1,637-patient study at the Texas Trauma Institute, the sepsis score had a sensitivity of 92.5% and a specificity of 97.4%, and its use was associated with a reduction in 30-day mortality in intensive care. Medscape (free registration) (01/23)

2. Organ transplants have saved more than 2 million years of life, study finds

AABB SmartBrief | Jan 29, 2015

A study in JAMA Surgery has found that organ transplants saved more than 2 million years of life from 1987 to 2012, with an average of more than four years of life saved for every transplant recipient. Kidney transplants were credited with saving 1.3 million years of life, followed by liver transplants at 460,000 years and heart transplants at nearly 270,000. HealthDay News (01/28)

3. Analysis examines pneumonia risk after heart surgery transfusions

AABB SmartBrief | Jan 28, 2015

An analysis of data involving more than 16,000 patients who had bypass surgery from 2011 to 2013 found that those who had red blood cell transfusions developed pneumonia at higher rates. The risk of pneumonia was twice as high for patients who received one or two units of blood compared with patients who did not receive a transfusion. Transfusions of six units or more were associated with a 14-fold increase in risk. The findings were reported at a meeting of the Society of Thoracic Surgeons. HealthDay News (01/27)

4. Ebola virus is mutating, French institute finds

AABB SmartBrief | Jan 30, 2015

Scientists at the Pasteur Institute in France have warned that strains of the Ebola virus in Guinea have mutated, and they are investigating whether the changes have made it more contagious. There have been several cases in which the patients showed no symptoms, according to a Pasteur geneticist. BBC (01/29)

5. Higher magnesium levels linked with improved outcomes in dialysis, study finds

AABB SmartBrief | Jan 28, 2015

Higher levels of magnesium were associated with better cardiovascular outcomes among dialysis patients with hyperphosphatemia, according to a study in the journal PLOS One. Researchers analyzed data involving more than 142,000 patients and found that cardiovascular mortality was more frequent in patients with low and intermediate magnesium levels. Renal and Urology News (01/27)

6. Stem cell-derived myocardial tissue is tested in preclinical study

AABB SmartBrief | Jan 27, 2015

Transplanted myocardial cells derived from induced pluripotent stem cells were incorporated into the hearts of rats in a study of myocardial infarction, according to researchers at Osaka University. The study team used X-ray imaging from Japan's SPring-8 synchrotron radiation facility to confirm that the implanted cells had integrated into the heart tissue. Yahoo (01/27)

7. Cancer immunotherapies come with risk of complications

AABB SmartBrief | Jan 28, 2015

Immunotherapies that use CAR T-cells and bispecific antibodies have shown promise against treatment-resistant blood cancers in trials, but researchers have also found a risk of adverse events related to the release of inflammatory chemicals. Cytokines can enter the bloodstream and cause side effects such as fever, low blood pressure and rapid heart rates. Reuters (01/26)

8. Human stem cells differentiated into hair-growing cells in study

AABB SmartBrief | Jan 28, 2015

Researchers used human stem cells to create dermal papillae that grew hair after being transplanted into immune-deficient mouse models, according to a study in the journal PLOS One. The cells were first induced to develop as neural crest cells before being differentiated into hair-producing cells. San Diego Union-Tribune (01/26)

9. January issue of AABB News highlights PBM around the world

AABB SmartBrief | Jan 26, 2015

While they may take different names, patient blood management principles are used by professionals worldwide. The January issue features snapshots of activities in six countries with established PBM programs -- Australia, Canada, Germany, the Netherlands, Spain and the United Kingdom. In addition, the article highlights PBM efforts in the United States as well as AABB's new director of patient blood management. Blank (01/26)

10. Burn clinic to test use of marrow-derived stem cells

AABB SmartBrief | Jan 26, 2015

Researchers at the University of Miami are conducting a study of the use of stem cells for the treatment of severe burns. Mesenchymal stem cells will be collected from patients' bone marrow and injected into the damaged skin every two weeks. Miami Herald (tiered subscription model), The (01/25) Inquisitr, The (01/25)

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