Addition of crenolanib to leukemia regimen shows promise | Newborns treated early for HIV show sustained remission | Study: SARS-CoV-2 remnants linger for years
March 12, 2024
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A study found that patients with B cell acute lymphoblastic leukemia who were treated with CAR T cell therapy after post-transplant relapse had superior outcomes and significantly better overall survival and progression-free survival rates compared with patients who received alternative therapies. The results were presented at the European CAR T-cell Meeting.
Full Story: Healio (free registration) (3/11) 
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Science & Health
A study in the Journal of Clinical Oncology found that adding crenolanib to an intensive chemotherapy regimen was safe and tolerated by adults with newly diagnosed FLT3-mutant acute myeloid leukemia. Crenolanib plus intense chemotherapy elicited an overall response rate of 90% among patients ages 60 and younger, and 80% among patients older than 60.
Full Story: Hematology Advisor (3/11) 
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In a study involving 54 newborns with HIV, scientists found that early treatment with antiretroviral drugs resulted in four children with sustained remission for at least four years, according to research presented at the Conference on Retroviruses and Opportunistic Infections. While the researchers stress that this isn't a cure, these findings suggest that early intervention could be an effective strategy to help manage pediatric HIV patients.
Full Story: Science (3/7) 
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Researchers have discovered that remnants of SARS-CoV-2 can persist in blood and tissue for more than a year after initial infection, shedding light on the phenomenon of long COVID. The findings, presented at the Conference on Retroviruses and Opportunistic Infections, showed SARS-CoV-2 antigens in blood for up to 14 months and in tissue samples for over two years post-infection, suggesting a potential link between these lingering remnants and long-term symptoms experienced by some people.
Full Story: Medscape (3/11) 
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Emerging Trends
Artificial intelligence that analyzed routinely collected clinical information predicts risks for severe complications related to postpartum hemorrhage, according to a study presented at a Society for Maternal-Fetal Medicine meeting. The model's accuracy increased from pre- to intra to postpartum and identified key predictive factors at each stage.
Full Story: Medscape (3/7) 
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Industry News & Practice
Michigan became the first state to sign with bluebird bio on a Medicaid outcomes-based coverage agreement for the sickle cell disease gene therapy Lyfgenia. About half of patients with sickle cell disease in the US are covered by Medicaid, and bluebird said it is in talks to sign similar deals with at least 15 agencies that represent 80% of Medicaid beneficiaries in the US.
Full Story: Fierce Pharma (3/11) 
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Government & Regulatory
The FDA has approved extensions to the shelf life of intravenous immunoglobulin therapies Asceniv and Bivigam to allow 36-month room temperature storage, up from four weeks. "We believe that this added storage flexibility for both [IVIG therapies] will meaningfully enhance our products' market offerings, enabling more versatile utilization and better inventory management for providers," said Adam Grossman, president and chief executive officer of ADMA Biologics.
Full Story: Pharmacy Times (3/11) 
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Health care organizations and health systems have asked congressional leaders to extend for five or more years the Acute Hospital Care at Home Waiver, which was enacted by the CMS during the COVID-19 pandemic and will expire at the end of the year without action from Congress. The signees note that without an extension, Medicare beneficiaries will lose access to hospital-at-home care, and they add that the waiver enables hospitals to address logistics surrounding hospital-at-home care and encourages other payers to participate.
Full Story: Fierce Healthcare (3/11) 
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Association News
Today is the final day for AABB members to apply to serve on a committee for the 2024-25 Association year. Positions are available for committee and junior committee members. AABB strongly encourages members who have not previously served on an AABB committee to apply. Those with questions about AABB committees or the application process may contact pep@aabb.org.
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