PET study links healthy lifestyle to reduced Alzheimer's progression | Study links duration of excess weight to increased cancer risk in women | Collaboration leads to clues about who will benefit from immunotherapy
August 18, 2016
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PET study links healthy lifestyle to reduced Alzheimer's progression
Researchers at the University of California at Los Angeles who used FDDNP-PET imaging found that regular physical activity, a healthy BMI and a Mediterranean diet were tied to lower levels of beta-amyloid plaques and tau protein tangles related to Alzheimer's in adults. The findings in The American Journal of Geriatric Psychiatry, based on scans from 44 individuals with either subjective memory impairment or mild cognitive impairment but without dementia, ages 40 to 85, suggest "the importance of living a healthy life to prevent Alzheimer's, even before the development of clinically significant dementia," said lead researcher Dr. David Merrill.
Medical News Today (8/17),  HealthDay News (8/17) 
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Clinical News & Research
Study links duration of excess weight to increased cancer risk in women
Study links duration of excess weight to increased cancer risk in women
(AFP/Getty Images)
A longitudinal study in the journal PLOS Medicine found women had a 10% increased risk of developing breast, endometrial, kidney or colon cancer for every 10 years of being obese and a 7% greater risk for every decade of being overweight. The findings, based on 73,913 women in the US who were enrolled in the Women's Health Initiative, also showed that the risk of obesity-related cancers depended on the degree of overweight.
CNN (8/16),  HealthDay News (8/16) 
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Collaboration leads to clues about who will benefit from immunotherapy
An immunologist helping his stepmother through metastatic melanoma treatment and the oncologist who treated her reported in the Journal of Clinical Investigation that they identified an immune-system cell type that predicts cancer's response to checkpoint inhibitors.
The Wall Street Journal (tiered subscription model) (8/15) 
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Study: Depression often underdiagnosed or poorly treated in older adults
A study in the American Journal of Geriatric Psychiatry finds depression often is underdiagnosed, untreated or inappropriately treated in adults ages 60 and older. Iqbal Ahmed, M.D., of the Uniformed Services University of Health Sciences in Maryland, commented that solutions may include efforts to reduce the stigma of mental illness, better physician education, and more widespread screening using questionnaires such as the Geriatric Depression Scale.
Medscape (free registration) (8/12) 
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Industry Report
Trial to combine tivozanib and nivolumab against kidney cancer
Aveo Oncology's cancer drug tivozanib will be combined with Bristol-Myers Squibb's immunotherapy Opdivo, or nivolumab, in a clinical trial for patients with advanced renal cell carcinoma. The FDA had closed the door to approval of tivozanib alone for treatment of the disease.
FierceBiotech (8/15) 
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Endo takes back sNDA application for opioid painkiller
Endo's supplemental new drug application to get its extended-release opioid painkiller Opana labeled as abuse deterrent has been withdrawn by the firm after a discussion with representatives from the FDA. The firm plans to continue its epidemiological research into abuse deterrence and could refile for an NDA at an unspecified time in the future.
The Wall Street Journal (tiered subscription model) (8/12),  Genetic Engineering & Biotechnology News (8/12) 
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News from the Field
Many hospitals lack language translators, study shows
More than one-third of US hospitals in low-need areas and one-fourth of hospitals in high- or moderate-need areas lack language interpreters for patients with limited English skills, potentially compromising patient care, researchers report in Health Affairs. Past research has found patients whose English proficiency is limited tend to be hospitalized longer, and they are more likely to be misdiagnosed or experience medical errors.
Reuters (8/11) 
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Health Policy
Ill. law regulates training for dementia caregivers
A law setting training standards for caregivers of Alzheimer's disease patients was signed into law by Illinois Gov. Bruce Rauner. The law includes provisions on length of training and curriculum, and creates advertising guidelines for companies that provide care to patients with Alzheimer's disease and other types of dementia.
WQAD-TV (Moline, Ill.)/The Associated Press (8/16) 
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Advancing Health Care
Providers can improve clinical workflow by following EHR best practices
Providers must develop a workflow plan before an EHR implementation project to avoid potential disruptions, and they should include technology and workflow experts on the team to achieve workflow goals. EHRs can be used to enhance care coordination across a care team and to improve clinical documentation to help boost the quality of patient care and hospital efficiency.
EHR Intelligence (8/15) 
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Call for abstracts opening Aug. 31
Beginning Aug. 31, 2016, young professionals, including residents, physicians or scientists in training or in practice within 10 years of graduation, are invited to submit an original abstract for the SNMMI Mid-Winter and ACNM Annual Meeting, Jan. 19-22, 2017, in Phoenix, Ariz. Contact me when the 2017 Call for Abstracts opens.
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New review course covers the essential topics in nuclear medicine
Take SNMMI's recently released online nuclear medicine review course -- covering the most essential topics in nuclear medicine -- and gain the level of expertise you need to ace your exam! AMA PRA Category 1 credits available. Learn more about this indispensable study tool.
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I have learned over the years that when one's mind is made up, this diminishes fear.
Rosa Parks,
civil rights activist
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The news summaries appearing in SNMMI SmartBrief are based on original information from multiple internet sources and are produced by SmartBrief, Inc., an independent e-mail newsletter publisher. The items above are not selected or reviewed by SNMMI prior to publication. Questions and comments may be directed to SmartBrief at
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