BP control may reduce odds of dementia in older adults, study finds | Study links TBI to higher risk of dementia | Scientists identify 40 potential drug targets in multiple myeloma study
April 13, 2018
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BP control may reduce odds of dementia in older adults, study finds
Researchers examined more than 1,200 African-Americans ages 65 and older who received ACE inhibitors, beta blockers, calcium channel blockers or diuretics for hypertension found that reduced blood pressure, and not antihypertensive drugs themselves, was associated with a lower likelihood of dementia. The findings in the Journal of General Internal Medicine suggest that BP control at all ages may curb dementia risk, said researcher Michael Murray.
HealthDay News (4/12) 
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Clinical News & Research
Study links TBI to higher risk of dementia
Research published in Lancet Psychiatry found patients who had any type of traumatic brain injury had a 24% higher risk of dementia than those who did not experience a TBI. Even experiencing one mild TBI increased the risk of dementia by 17%.
The New York Times (tiered subscription model) (4/10) 
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Scientists identify 40 potential drug targets in multiple myeloma study
Scientists identify 40 potential drug targets in multiple myeloma study
(Tim Sloan/AFP/Getty Images)
Forty genes have been identified by investigators from London's Institute of Cancer Research that could become potential therapeutic targets. As reported in the journal Leukemia, the researchers were able to pinpoint coding and noncoding mutations linked to the development of multiple myeloma while examining whole-genome sequencing data from 765 patients.
GenomeWeb Daily News (free registration) (4/9) 
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Brain development changes found in infants with prenatal SSRI exposure
A study in JAMA Pediatrics showed that babies whose mothers took selective serotonin reuptake inhibitors for depression during pregnancy had significantly increased brain volume in the right amygdala and right insula, which are involved in emotional processing, as well as significantly greater connectivity between both brain regions, compared with those whose mothers had untreated depression and those whose mothers didn't have depression. The findings should prompt "further research on the potential long-term behavioral and psychological outcomes of these neurodevelopmental changes," researchers said.
Physician's Briefing/HealthDay News (4/9),  Reuters (4/9) 
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Industry Report
FDA grants fast-track designation to Karyopharm's multiple myeloma drug
Selinexor, Karyopharm Therapeutics' treatment for patients with multiple myeloma who have undergone at least three previous lines of therapy, was granted fast-track designation by the FDA. Top-line data from a study evaluating the drug is expected to be released by the end of the month.
Seeking Alpha (free registration) (4/10),  MarketWatch (4/10) 
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Keytruda meets endpoint in lung cancer trial
A late-stage trial of Merck's Keytruda extended survival of treatment-naive patients with lung cancer, according to the company.
Reuters (4/9) 
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News from the Field
AHA: Costs of informal caregiving in CVD to hit $128B in 2035
An American Heart Association policy statement published in the journal Circulation estimated the cost of informal caregiving for patients with cardiovascular disease will increase from $61 billion in 2015 to $128 billion in 2035. The AHA called for the development of a national caregiving strategy, expanded access to palliative care, the incorporation of outcomes and caregiver engagement to payment reforms, and prioritizing caregiving research.
Healio (free registration)/Cardiology Today (4/9) 
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Health Policy
MedPAC considers expanding incentives for risk-based contracts
Medicare Payment Advisory Commission members discussed expanding incentives for health care providers participating in advanced alternative payment models under the Medicare Access and CHIP Reauthorization Act in an effort to encourage more participation. The commission proposed paying a 5% bonus only on certain revenue derived from an AAPM.
FierceHealthcare (4/10) 
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Advancing Health Care
Higher physician satisfaction seen with specialty EHR products
Specialist-focused EHR products for categories such as nephrology, cardiology, addiction medicine and endocrinology received the highest satisfaction scores in a Black Book survey of 18,950 physician practices. Epic Systems received the highest satisfaction scores in neurosurgery, transplant medicine and nephrology, athenahealth ranked highest in endocrinology, and NextGen scored highest for multispecialty clinics, general practice, and obstetrics and gynecology.
EHR Intelligence (4/9) 
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Attend a free "Fluciclovine Live Training Session" at SNMMI's Annual Meeting
Want to learn how to interpret Fluciclovine F-18 scans in recurrent prostate cancer patient from the experts? Register now to join us on Saturday, June 23, at the SNMMI 2018 Annual Meeting for this 3-hour, hands-on, case review training session. Please note: registration is complimentary, but separate from your Annual Meeting registration. Space is limited to the first 100 registrants. Register now.
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Prepare for the NMTCB's nuclear cardiology specialty examination
Developed by a team of leading nuclear cardiology technologists, the Nuclear Cardiology Technology Study Guide, 2nd edition, will enhance and reinforce your knowledge of cardiac anatomy, physiology, pathology and electrophysiology as you prepare for the NMTCB's nuclear cardiology specialty examination. VOICE credit is available! Learn more.
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The news summaries appearing in SNMMI SmartBrief are based on original information from multiple internet sources and are produced by SmartBrief, Inc., an independent e-mail newsletter publisher. The items above are not selected or reviewed by SNMMI prior to publication. Questions and comments may be directed to SmartBrief at snmmi@smartbrief.com.
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