PET study sheds light on varying tau size, spread among Alzheimer's patients | Pediatric chronic illness tied to increased mental health risks in adulthood | Microglia may hold clues to why more boys develop autism than girls
May 17, 2017
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News for nuclear medicine and molecular imaging professionals
Researchers who used PET found significant differences among patients with Alzheimer's disease in tau deposit size and how rapidly deposits spread that might explain differences in disease progression, and they found that deposit size was strongly correlated with episodic memory impairment. The findings in Molecular Psychiatry "can improve understanding of tau accumulation in Alzheimer's disease, help ongoing research to quantify the effect of tau vaccines and enable early diagnosis," said researcher Agneta Nordberg.
UK researchers found that children with chronic physical illnesses such as asthma, arthritis, cancer, chronic renal failure, congenital heart disease, cystic fibrosis, epilepsy and type 1 diabetes were more likely to develop anxiety and depression that persisted into adulthood, compared with those without such conditions. The findings in the Journal of Child Psychology and Psychiatry were based on a review of 37 studies involving more than 45,000 youths.
The number of microglia, the cells that trim neural connections, vary between sexes and may explain why more boys are diagnosed with autism than girls, according to preliminary findings presented at the International Meeting for Autism Research. Scientists say they've found that genes associated with those cells are more active in the brains of boys.
Hereditary cerebral cavernous malformations are blood-filled bubbles that protrude from veins in the brain, and a study published in Nature suggests that antibiotics and fecal transplants might treat the condition. Researchers found that a genetic defect allows lipopolysaccharides carried in Gram-negative bacteria in the gut to cause veins in the brain to form blood bubbles, and antibiotics and microbiome replacement prevented or halted disease progression in lab mice.
A biologics license application has been submitted by Eli Lilly and Co. for its monthly self-administered injection galcanezumab, a monoclonal antibody indicated to treat migraines. The submission was backed by positive data from a late-stage study in which treatment with the drug showed a significantly reduced number of migraine headache days each month.
A Gundersen Health System study published in the Journal of the National Comprehensive Cancer Network showed a disconnect between cancer patients and oncologists on the issue of exercise recommendations. Researcher Agnes Smaradottir said patients thought exercise was important to their treatment and wanted their oncologist to recommend a home-based plan, but the physicians were reluctant to do that and often referred patients to rehabilitation.
House Speaker Paul Ryan, R-Wis., said the fiscal 2018 budget resolution may contain changes to the Medicare program, noting he has long included Medicare changes in his budgets. As the Senate works on health care, Ryan said he also intends to focus on overhauling the tax code by the end of 2017.
The health care industry should be wary in their online activities after the WannaCry ransomware cyberattack against hospitals and health information systems across the world last week, according to HHS and other US agencies. HHS suggested several steps on how organizations could prevent ransomware attacks, and the US Computer Emergency Readiness Team said organizations should not pay a requested ransom.
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You can have the nine greatest individual ballplayers in the world, but if they don't play together, the club won't be worth a dime.
Babe Ruth, baseball player
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