Scientists developing total-body PET scanner for pediatric patients | Study: Midlife health factors may increase dementia risk | PPI use not linked to Alzheimer's disease, study says
August 10, 2017
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Scientists developing total-body PET scanner for pediatric patients
Researchers at Ghent University and the Vrije Universiteit Brussels are developing a new high-resolution total-body PET scanner with a 2 m field-of-view called PET20.0, which will have 20 times increased sensitivity compared with current PET scanners, as well as better spatial resolution than the EXPLORER total-body PET scanner. The PET20.0, which is poised to be completed by 2020, will bolster imaging quality for pediatric patients and allow for novel applications that can evaluate breakthrough treatment plans in conventional radiotherapy and chemotherapy, researchers said.
Medical Physics Web (registration required) (8/9) 
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Clinical News & Research
Study: Midlife health factors may increase dementia risk
Midlife heart-related health factors associated with an increased risk of dementia include diabetes, high blood pressure, pre-high blood pressure and smoking, according to a study in JAMA Neurology. Having diabetes increased the risk of dementia almost as much as having the APOE-e4 gene, which is a genetic risk factor for Alzheimer's disease, researchers found.
HealthDay News (8/7) 
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PPI use not linked to Alzheimer's disease, study says
The use of proton pump inhibitors is not associated with higher risks of Alzheimer's disease, even among patients using the drugs for more than three years or taking them at higher dosages, according to a study in The American Journal of Gastroenterology. The study included data from nationwide health care registers in Finland.
Nursing Times (U.K.) (free registration) (8/7) 
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New gene discovery could lead to improved immunotherapies
A study in the journal Nature that used a genome-wide CRISPR-based screening program identified protein-coding genes that a cancerous tumor must express for immune checkpoint inhibitor drugs to be effective. The goal is to use the genes to develop better immunotherapies and to help cancer patients who have not had success with them to achieve a response.
The Scientist online (8/7) 
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Industry Report
Novartis approaches Yale for T-cell therapy candidate's rollout
The Yale School of Medicine has been contacted by Novartis to become a rollout site for a chimeric antigen receptor T-cell therapy developed to treat B-lineage acute lymphoblastic leukemia. The Oncologic Drugs Advisory Committee has recommended approval of the therapy.
New Haven Register (Conn.) (8/6) 
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Keytruda fails cost-effectiveness for urothelial cancer drug, NICE panel says
In an appraisal consultation document, the National Institute for Health and Care Excellence recommended against MSD's Keytruda, or pembrolizumab, as a treatment for adult patients with locally advanced or metastatic urothelial cancer who have undergone treatment with platinum-containing chemotherapy. NICE did not consider the drug cost-effective.
PharmaTimes (U.K.) (8/4) 
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News from the Field
Study: Transition to value-based care may increase burnout
A study in Health Affairs that included 296 practice sites involved in the CMS Advanced Primary Care Demonstration project found the transition to value-based care, including achieving medical home recognition, may increase staff burnout and dissatisfaction. Rand Corp. researcher Mark Friedberg said while other factors could have affected burnout, it is important to consider these issues as health care transitions to value-based models.
Modern Healthcare (tiered subscription model) (8/7) 
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Health Policy
No emergency declaration needed for opioid crisis, administration says
No emergency declaration needed for opioid crisis, administration says
(Pool/Getty Images)
HHS Secretary Tom Price said there is no need to declare the opioid abuse epidemic a national public health emergency, as recommended by the White House's opioid commission, because the administration already has the ability to take action to curb the crisis, although the idea was not taken off the table entirely. President Donald Trump said his administration will fight the opioid crisis by strengthening law enforcement and security along the southern border to prevent drugs from entering the US.
The Washington Post (tiered subscription model) (8/8),  The Hill (8/8),  Politico (8/8) 
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Advancing Health Care
Mobile app may benefit patients with depression
MoodTrek, a mobile app developed by Dr. Ganesh Gopalakrishna, a psychiatrist at the University of Missouri Health Care, along with a computer scientist at the Missouri University of Science and Technology, gathers data about the moods, sleep and physical activity of depression patients and uploads it instantly into their EHRs. A small study found that app users increased their prescription drug treatment and decreased emergency department use.
Hospitals & Health Networks Magazine (8/7) 
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SNMMI 2017 Annual Meeting commemorative T-shirts
A limited number of SNMMI Annual Meeting commemorative T-shirts are still available for purchase. These cotton T-shirts arrive in a special custom box, complete with sunglasses! Grab yours before they're gone! Order today.
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The news summaries appearing in SNMMI SmartBrief are based on original information from multiple internet sources and are produced by SmartBrief, Inc., an independent e-mail newsletter publisher. The items above are not selected or reviewed by SNMMI prior to publication. Questions and comments may be directed to SmartBrief at snmmi@smartbrief.com.
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