Agents show promise in colorectal cancer detection | Study IDs key mechanism in Parkinson's disease | Genetic test identifies patients at risk of atrial fibrillation and stroke
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October 17, 2014
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News for nuclear medicine and molecular imaging professionals

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Agents show promise in colorectal cancer detection
A study in the journal PLOS One suggests that Cellectar Biosciences' phospholipid ether analog agents CLR1502 and iodine-131 CLR1404 could provide better localization of primary and metastatic tumors in patients with colorectal cancer. Findings revealed that CLR1502 uptake in intestinal tumors distinguished malignant from nonmalignant tissues in animal models and could also detect regional lymph nodes, while iodine-131 CLR1404 was taken up by colon cancer metastases in humans and could be used in PET. (free registration) (10/16)
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Clinical News & Research
Study IDs key mechanism in Parkinson's disease
A fruit fly study in Nature Communications suggests Parkinson's disease progression could be stalled with the help of deacetylase inhibitors that target neuronal transport defects caused by an LRRK2 mutation. The study on fruit flies carrying the mutation showed that when the protein produced by the LRRK2 gene binds to microtubules, nerve cells' transport processes are affected. Deacetylase inhibitors could be used to reverse those effects. (India)/Indo-Asian News Service (10/16)
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Genetic test identifies patients at risk of atrial fibrillation and stroke
Scientists have developed a test that screens for 12 genetic variants to determine risk of ischemic stroke and atrial fibrillation, according to a study in the journal Stroke. Adding the genetic score to risk models for atrial fibrillation could help correctly assess when anticoagulants are needed, particularly among patients younger than 65. Healio (free registration)/Cardiology Today (10/15)
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Industry Report
Bayer suspends radium-223 production
Bayer HealthCare Pharmaceuticals has halted production of prostate cancer drug radium-223, sold as Xofigo, because of problems with manufacturing. Supplies of the drug have been limited since Oct. 7, according to the FDA. Bayer said it is communicating with the FDA and providers about the issue, but it had no estimate regarding when production will resume. OncLive (10/15)
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N.H. breast-imaging device startup obtains $6.5M
A regulatory filing shows that Gamma Medica has obtained $6.5 million in its latest funding round. The New Hampshire-based startup makes the LumaGEM molecular imaging system, an FDA-cleared device used as an ancillary tool to mammography in diagnosing breast cancer in women with dense breasts. (10/15)
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News from the Field
Group issues recommendations on advancing MU
The American Medical Association has issued recommendations to help bolster EHR functionality and health care quality. Some of the strategies suggested include improving alignment of meaningful use criteria, restructuring EHR certification and keeping quality measures updated. Clinical Innovation + Technology online (10/15)
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Health Policy
Forum seeks comments on problematic-device reporting proposal
A document issued by the International Medical Device Regulators Forum outlines the group's proposal to modify its process for exchanging data on serious public health threats tied to medical devices sold in its member countries. The proposal, which outlines information such as the criteria for determining when data should be shared, how it should be shared and the requirements for participating in the exchange program, is up for comment through Dec. 8. Clinica (subscription required) (10/14)
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WHO agency issues 12-point code for cancer prevention
The World Health Organization's International Agency for Research on Cancer issued guidelines that researchers say could prevent as much as 50% of all new cancer cases in Europe. The guide calls for avoiding tobacco, exercising, eating a healthy diet, minimizing exposure to ultraviolet light and getting regular cancer screenings. Reuters (10/14)
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Advancing Health Care
Robot goes through the cheek to reach hard-to-access part of brain
(John MacDougall / AFP / Getty Images)
A robotic surgical device that enters a patient through the cheek provides better access for surgeons needing to access the bottom of the brain. The device developed by engineers at Vanderbilt University uses a needle driven by compressed air to advance incrementally, much like a mechanical pencil, along a curving path until it reaches its destination. Gizmag (10/15)
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Online registration is now available for the SNMMI 2015 Mid-Winter Meeting
Make your plans to attend SNMMI's Mid-Winter Meeting -- Jan. 22-25 in San Antonio -- for a first-class program highlighting advances in hybrid imaging, SPECT and amyloid PET, the role of PET/MRI in molecular imaging, targeted radionuclide therapy, translational cardiovascular imaging, quantitative PET imaging and emerging technologies. Plus, the two-day 100-CT and 20-MRI Case Review offers CME and case credit for meeting the CT/MRI training and credentialing recommendations. Register today.
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Now available: PET Online Review Workshop. VOICE credit available
The new PET Online Review Workshop has been designed to help nuclear medicine professionals develop the essential level of understanding in PET and PET/CT needed to pass the NMTCB's PET Exam. Focusing on the fundamentals of PET imaging in oncology, cardiology and neurology, this online program includes comprehensive lectures covering the NMTCB's content outline, as well as a mock exam. Learn more!
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People are like stained-glass windows. They sparkle and shine when the sun is out, but when the darkness sets in, their true beauty is revealed only if there is a light from within."
-- Elisabeth Kubler-Ross,
American psychiatrist
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The news summaries appearing in SNMMI SmartBrief are based on original information from multiple internet sources and are produced by SmartBrief, Inc., an independent e-mail newsletter publisher. The items above are not selected or reviewed by SNMMI prior to publication. Questions and comments may be directed to SmartBrief at
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