PET study sheds light on varying tau size, spread among Alzheimer's patients | Pediatric chronic illness tied to increased mental health risks in adulthood | Microglia may hold clues to why more boys develop autism than girls
May 17, 2017
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PET study sheds light on varying tau size, spread among Alzheimer's patients
Researchers who used PET found significant differences among patients with Alzheimer's disease in tau deposit size and how rapidly deposits spread that might explain differences in disease progression, and they found that deposit size was strongly correlated with episodic memory impairment. The findings in Molecular Psychiatry "can improve understanding of tau accumulation in Alzheimer's disease, help ongoing research to quantify the effect of tau vaccines and enable early diagnosis," said researcher Agneta Nordberg.
Health Imaging online (5/16) 
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Clinical News & Research
Pediatric chronic illness tied to increased mental health risks in adulthood
UK researchers found that children with chronic physical illnesses such as asthma, arthritis, cancer, chronic renal failure, congenital heart disease, cystic fibrosis, epilepsy and type 1 diabetes were more likely to develop anxiety and depression that persisted into adulthood, compared with those without such conditions. The findings in the Journal of Child Psychology and Psychiatry were based on a review of 37 studies involving more than 45,000 youths.
United Press International (5/12) 
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Microglia may hold clues to why more boys develop autism than girls
The number of microglia, the cells that trim neural connections, vary between sexes and may explain why more boys are diagnosed with autism than girls, according to preliminary findings presented at the International Meeting for Autism Research. Scientists say they've found that genes associated with those cells are more active in the brains of boys.
Nature (free content) (5/12) 
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Study finds link between microbiome, brain defect
Hereditary cerebral cavernous malformations are blood-filled bubbles that protrude from veins in the brain, and a study published in Nature suggests that antibiotics and fecal transplants might treat the condition. Researchers found that a genetic defect allows lipopolysaccharides carried in Gram-negative bacteria in the gut to cause veins in the brain to form blood bubbles, and antibiotics and microbiome replacement prevented or halted disease progression in lab mice.
The New York Times (free-article access for SmartBrief readers) (5/10) 
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Industry Report
BLA for migraine drug filed by Eli Lilly
A biologics license application has been submitted by Eli Lilly and Co. for its monthly self-administered injection galcanezumab, a monoclonal antibody indicated to treat migraines. The submission was backed by positive data from a late-stage study in which treatment with the drug showed a significantly reduced number of migraine headache days each month.
Genetic Engineering & Biotechnology News (5/12) 
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FDA accepts AFT's registration for its painkiller drug
AFT Pharmaceuticals' application to register its painkiller Maxigesic tablets in the US has been accepted by the FDA.
Reuters (5/11) 
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News from the Field
Doctors, cancer patients have different views on exercise
A Gundersen Health System study published in the Journal of the National Comprehensive Cancer Network showed a disconnect between cancer patients and oncologists on the issue of exercise recommendations. Researcher Agnes Smaradottir said patients thought exercise was important to their treatment and wanted their oncologist to recommend a home-based plan, but the physicians were reluctant to do that and often referred patients to rehabilitation.
La Crosse Tribune (Wis.) (5/16) 
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Health Policy
Ryan hopes to include Medicare changes in 2018 budget
Ryan hopes to include Medicare changes in 2018 budget.
Ryan (Chip Somodevilla/Getty Images)
House Speaker Paul Ryan, R-Wis., said the fiscal 2018 budget resolution may contain changes to the Medicare program, noting he has long included Medicare changes in his budgets. As the Senate works on health care, Ryan said he also intends to focus on overhauling the tax code by the end of 2017.
Roll Call (free content) (5/12) 
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Advancing Health Care
US agencies: Health care should exercise caution following global cyberattacks
The health care industry should be wary in their online activities after the WannaCry ransomware cyberattack against hospitals and health information systems across the world last week, according to HHS and other US agencies. HHS suggested several steps on how organizations could prevent ransomware attacks, and the US Computer Emergency Readiness Team said organizations should not pay a requested ransom.
Health IT Security (5/15) 
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Get ideas and tips to take the plunge and advance your career -- June 29 at 3 p.m. ET
In the field of nuclear medicine, the initials CNMT get you in the door. Now opportunities for growth and development are abundant, from advanced practice and research to leadership and management roles in the clinic and industry. Join Ruth Tesar and Lance Burrell for a June 29 webinar exploring some of these exciting areas and providing an overview that might lead you to your next adventure. Register today.
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Now with CE credit: "Myocardial Perfusion Imaging 2016: Quality, Safety, And Dose Optimization"
This comprehensive book focuses on ways to improve quality, increase safety and reduce radiation burden in myocardial perfusion imaging. It is designed as an easy reference that will give new insights to even the most tenured technologists. The SNMMI, through its Verification of Involvement in Continuing Education (VOICE) program, has approved this mini-book for a maximum of 10.0 continuing education hours (CEHs). Get started today.
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The news summaries appearing in SNMMI SmartBrief are based on original information from multiple internet sources and are produced by SmartBrief, Inc., an independent e-mail newsletter publisher. The items above are not selected or reviewed by SNMMI prior to publication. Questions and comments may be directed to SmartBrief at
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