Weight loss tied to atrial fibrillation reversal, study finds | Researchers create glucose response curve patterns for people without diabetes | Incident diabetes, CVD tied to genetic risk, lifestyle, study shows
July 5, 2018
News about cardiovascular disease prevention and management
Australian researchers used a cohort of 355 patients with atrial fibrillation and obesity and found that more of those who lost at least 10% of their weight experienced a reverse progression of Afib after four years, compared with those who lost less than 3% of their weight. The findings in the journal Europace also revealed that 88% of those who lost at least 10% of their weight did not have Afib in the past year or had gone from persistent to paroxysmal Afib.
A study in Diabetes Care identified four different glucose response curve patterns that could help differentiate cardiometabolic risk factors among patients without diabetes. The glucose response curve patterns were based on measurements of plasma glucose, serum insulin and C-peptide concentrations at 5 time points during an oral glucose tolerance test, and have been formatted into an online app for purposes outside this study.
Researchers found that genetic risk and lifestyle were independent predictors of incident type 2 diabetes and cardiovascular disease. The findings in JAMA Cardiology, based on data from 339,003 individuals of white British descent from the UK Biobank, revealed that the hazard ratio for poor lifestyle among those with high genetic risk was up to 15.46 for diabetes, 5.41 for atrial fibrillation, 4.68 for hypertension, 4.54 for coronary artery disease and 2.26 for stroke, compared with those who had low genetic risk and an ideal lifestyle.
A pooled real-world analysis of data from studies involving more than 11,000 patients with atrial fibrillation from 47 countries found that users of the anticoagulant Xarelto, or rivaroxaban, had a similar or lower risk for stroke and major bleeding compared with clinical trial data, as reported in the Journal of the American College of Cardiology. The rate of major bleeding was 1.7 per 100 patient-years, and a one-year rate of stroke or systemic embolism was 1 per 100 patient-years.
A draft consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes presented at the ADA's annual meeting highlights the importance of assessing patients first for cardiovascular disease, then other comorbidities and personal preferences at the start of treatment for type 2 diabetes. The final version of the document will be presented at the EASD annual meeting in October and will be published in Diabetes Care and Diabetologia.
Registered nurse tops job portal Monster's list of the top 10 in-demand jobs. Monster's list of top employers hiring for the first half of 2018 includes Brookdale Senior Living, Kindred at Home and Kindred Healthcare, and Mercy Health.