Research links limb pain with migraine spectrum | Mouse study identifies gene that may be linked with delayed opioid tolerance | Study says medial septum may help moderate pain levels
November 18, 2015
News for the pain professional

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Research links limb pain with migraine spectrum
Limb pain may be part of the migraine spectrum in children and adults, according to researchers who completed a four-generation study that included 27 family members and lasted eight years. Researchers presented the study at the World Congress of Neurology and said limb pain can be intermittent during migraines, cluster headaches or cluster migraines, and also can occur without the presence of a headache. Medscape (free registration) (11/13)
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Mouse study identifies gene that may be linked with delayed opioid tolerance
People with mutations of the gene RGS7, which regulates morphine receptor signaling in certain brain cells, could require lower doses of morphine and may be more likely to become addicted to opioids than people with the wild-type RGS7 gene, according to research reported in Biological Psychiatry. Studies in mice lacking the gene found that its absence was associated with delayed tolerance, increased pain relief and intensified withdrawal response. HCPLive (11/16)
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Treatment NewsAdvertisement
Ozone gas may reduce arthritis pain in knee, study says
Ozone injections reduced pain and improved function for patients with knee osteoarthritis, compared with a control group, according to a study presented at the American College of Rheumatology's annual meeting. Researchers injected the gas into the knee using a specially designed device. Medscape (free registration) (11/13)
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Cyclobenzaprine may reduce fibromyalgia symptoms
An analysis of data from the BESTFIT study found the use of sublingual cyclobenzaprine hydrochloride may help fibromyalgia patients with pain and trouble sleeping, researchers reported at the American College of Rheumatology's annual meeting. The placebo-controlled study found the treatment can take about four weeks to work, but can improve sleep quality, pain and other symptoms, said researcher Dr. Seth Lederman of Tonix Pharmaceuticals. Medscape (free registration) (11/17)
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10 Common Website Scenarios That Make a Web CMS Essential
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Policy & Trends
Pain management experts critical of CDC opioid guidelines
Pain management experts have criticized CDC draft guidelines to reduce opioid abuse and addiction. Some say the guidelines will harm patients with chronic pain who are not at risk of abuse and who have no other treatment options. "The focus should not be on whether opioids should be used or not -- the focus should be on what a person in pain needs," said Dr. Lynn Webster. Pain Medicine News (11/2015)
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Researchers issue recommendations on reducing opioid abuse
Johns Hopkins researchers issued a comprehensive report containing evidence-based guidelines for dealing with opioid prescription drug abuse in the US. Recommendations include changes in training for medical students and physicians and in how the drugs are dispensed and monitored. Medscape (free registration) (11/16)
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APS News
Rita Allen Foundation Award in Pain -- Now open
The Rita Allen Foundation (RAF) and APS together may award two grants in the amount of $50,000 annually, for a period of up to three years, to those research proposals demonstrating the greatest merit and potential for success. Eligible candidates will have completed their training and provided persuasive evidence of distinguished achievement or extraordinary promise in basic science research in pain. A complete application must be submitted via the proposalCENTRAL system by 11:59 p.m. Eastern Time on Jan. 18, 2016. Learn more.
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In an effort to increase funding opportunities for those who share APS’ vision of a world where pain prevention and relief are available to all people, we will take part in #GivingTuesday on Tuesday, Dec. 1. Established in 2012, #GivingTuesday is a global day dedicated to giving. APS encourages you to give to the APS Pain Research Fund on #GivingTuesday. With your contribution, you can make a difference in the pain community. Join our growing list of donors to help alleviate pain. Pain relief starts at research. Donate today.
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You cannot swim for new horizons until you have courage to lose sight of the shore."
-- William Faulkner,
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