Study describes development of leader cells in wound healing | Cartilage allograft gives young athlete a chance to play again | Review: Acidic environment can help promote wound healing

March 18, 2015
AATB SmartBrief
News for the Tissue Banking Community

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Study describes development of leader cells in wound healing
A study in the journal Nature Communications found that migrating wound-healing cells develop into leader and follower cells based on Dll4 protein signaling prompted by the cells' reaction to cell-free spaces in damaged tissue. "Time-lapse microscopy reveals that Dll4 is induced in leader cells after the creation of the cell-free region and leader cells are regulated via Notch1–Dll4 lateral inhibition," the researchers wrote. Genetic Engineering & Biotechnology News (3/16)
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Cartilage allograft gives young athlete a chance to play again
Sydney Boike is playing basketball for her Crookston High School team in Minnesota again after receiving an osteochondral allograft to treat a knee injury. Donated cartilage and bone were used to repair the joint. "Basketball has been such a passion for Sydney. The prospect of not being able to play was pretty scary," said Chris Boike, Sydney's mother. Grand Forks Herald (N.D.) (3/16)
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Government & Regulatory
House leaders seek permanent Medicare doc fix
Republican and Democratic House leaders are trying to construct a measure that would permanently overhaul the Medicare sustainable growth rate formula. The physician reimbursement rate will be cut by 21% on April 1 in the absence of congressional action. St. Louis Post-Dispatch/The Associated Press (3/11)
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WHO releases treatment guidelines for hepatitis B
The World Health Organization has issued guidelines for the treatment of hepatitis B. The recommendations include the use of noninvasive tests to determine the progression of liver disease, the prioritizing of treatment for patients with cirrhosis and treatment with tenofovir or entecavir. The WHO also called for children to be vaccinated against hepatitis B. (3/13)
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FDA issues final rules on reusable medical devices
The FDA has released stricter rules regarding the cleaning and disinfecting of reusable medical devices such as the endoscopes that have been blamed for recent superbug outbreaks at hospitals in California. Manufacturers will now be required to provide proof that the disinfecting instructions for their medical devices are effective before receiving FDA approval for those devices. Meanwhile, the CDC has recommended swabbing devices after they have been disinfected to make sure there are no microbes that have grown into detectable colonies before the device is used again. Reuters (3/12)
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Business & Economic Trends
Coriell receives $14 million grant for biobank
The National Institutes of Health has given a $14 million grant to the Coriell Institute to support the National Institute of General Medical Sciences Human Genetic Cell Repository. The biobank contains 11,300 cell lines and 5,700 DNA samples associated with 890 diseases and chromosomal abnormalities as well as control samples and 40 lines of induced pluripotent stem cells. GenomeWeb Daily News (free registration) (3/16)
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Cobas DPX assay from Roche gets CE mark
European regulators have granted Roche CE mark approval for its cobas DPX assay, which detects parvovirus B19 and hepatitis A virus in human plasma. The device, which is a real-time PCR test, is intended for use on the cobas 6800 and 8800 systems. GenomeWeb Daily News (free registration) (3/16)
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EU OKs precision medical instruments from JustRight Surgical
European regulators have granted JustRight Surgical CE mark approval to market all of its FDA-cleared precision medical devices in Europe. The designation includes the Boulder, Colo.-based firm's 5-mm surgical staple and Vessel Sealing System, which are intended for pediatric procedures that require access to delicate tissues or tight spaces. Daily Camera (Boulder, Colo.) (3/12)
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Other News
Register now for AATB's March webinar
  • Title: Rapid Antibody Pre-Screening for HBV, HCV and HIV-1/2 Prior to Tissue Recovery
  • Date: Thursday, March 26
  • Time: 2-3 p.m. (EST)
  • Read more!
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