Study describes development of leader cells in wound healing
A study in the journal Nature Communications found that migrating wound-healing cells develop into leader and follower cells based on Dll4 protein signaling prompted by the cells' reaction to cell-free spaces in damaged tissue. "Time-lapse microscopy reveals that Dll4 is induced in leader cells after the creation of the cell-free region and leader cells are regulated via Notch1–Dll4 lateral inhibition," the researchers wrote. Genetic Engineering & Biotechnology News
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WHO releases treatment guidelines for hepatitis B
The World Health Organization has issued guidelines for the treatment of hepatitis B. The recommendations include the use of noninvasive tests to determine the progression of liver disease, the prioritizing of treatment for patients with cirrhosis and treatment with tenofovir or entecavir. The WHO also called for children to be vaccinated against hepatitis B. BeckersHospitalReview.com
FDA issues final rules on reusable medical devices
The FDA has released stricter rules regarding the cleaning and disinfecting of reusable medical devices such as the endoscopes that have been blamed for recent superbug outbreaks at hospitals in California. Manufacturers will now be required to provide proof that the disinfecting instructions for their medical devices are effective before receiving FDA approval for those devices. Meanwhile, the CDC has recommended swabbing devices after they have been disinfected to make sure there are no microbes that have grown into detectable colonies before the device is used again. Reuters
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