Researchers reviewed data for more than 10,000 adults with atrial fibrillation and found that although women were more likely to experience symptoms and had a greater risk of stroke than men, they had lower odds of cardiovascular and all-cause mortality. The findings, published in JAMA Cardiology, also showed that men and women had similar rates of anticoagulant use.
Canadian researchers found four cases of diabetic ketoacidosis in three type 2 diabetes patients who underwent bariatric surgery, and all of the cases, which were classified as moderate to severe, manifested within 30 days after the procedure and required ICU admission. The findings in Diabetes Care also showed that the median time to DKA was 13 days and no cases were due to postoperative infectious complications.
Children with prenatal exposure to bisphenol A were more likely to have increased measures of obesity, including percent body fat, fat mass index and waist circumference, at age 7, according to a study in Environmental Health Perspectives. Researchers used a cohort of 1,301 children, whose urine samples were measured in the prenatal period and at ages 3 and 5.
Researchers looked at 4,373 adults who were followed for 20 years and found those with higher cardiorespiratory fitness had a lower risk of developing prediabetes or type 2 diabetes, according to a study in Diabetologia. A second study in the Journal of Applied Physiology showed that the risk of developing prediabetes or type 2 diabetes was reduced by 0.1% among people with an 8% to 11% improved fitness level.
Patients who use Invokana or Invokamet, Janssen's diabetes drugs that go by the generic name canagliflozin, could be two times more likely to have foot and leg amputations compared with a placebo group, the FDA warned in a safety alert. The alert is based on an ongoing clinical trial that found amputation rates for canagliflozin were seven per 1,000 patients at the 100 milligrams-per-day dose and five per 1,000 for the 300-milligram dose, but three per 1,000 for placebo. A second, similar study has not shown the same rates, and the FDA is still investigating if the drug increases amputation risk.
Swiss researchers found that 6% of women who took pain and epilepsy drug Lyrica, or pregabalin, during the first trimester of pregnancy had babies with major birth defects, such as heart defects and problems with the central nervous system or other organs, compared with 2% among those who didn't take the drug. The findings in Neurology, based on data involving 820 pregnant women, also showed that those who took the drug had a sixfold increased likelihood of having infants with major abnormalities in the central nervous system, compared with those who didn't.
A lower-than-expected rate of decline in pulmonary function was found after initiation of hydroxyurea treatment among 94 children and young adults with sickle cell disease, according to a 94-patient study presented at a meeting of the American Thoracic Society. The findings may be useful in promoting adherence, said Anya McLaren of the Hospital for Sick Children in Toronto.
Advocate Health Care, Illinois' largest health system, is taking over operations of more than 50 Walgreens clinics in eight counties in the Chicago area. The walk-in clinics are staffed by nurse practitioners and medical assistants, and they offer care such as physicals, vaccinations, and treatment for common sicknesses and injuries.
The House has passed a $622 million spending bill for preventing the spread of the Zika virus in the US. President Barack Obama, who requested $1.9 billion in funding, threatened to veto the legislation, while CDC Director Tom Frieden said that the House measure would be insufficient to address the growing threat from Zika.
Rep. Brett Guthrie, R-Ky., is considering changes to the nation's Medicaid program that could clear Congress as early as next year. One idea is to simplify the transition from Medicaid coverage to a commercial health plan as enrollees' incomes rise. Guthrie, who chairs the Energy and Commerce Committee's Medicaid task force, says he wants to make it easier for states to manage expanded Medicaid coverage under the Affordable Care Act.
The Patient Access Network Foundation and The American Journal of Managed Care seek papers that identify sustainable strategies for providing access to critical medications for Medicare and Affordable Care Act beneficiaries. PAN and AJMC also seek case studies that evaluate the impact out-of-pocket costs for medications have on patients' health care utilization, treatment adherence and outcomes. Case studies should describe innovative solutions or programs that help educate Medicare beneficiaries and ACA enrollees about ways to mitigate financial toxicity and how to use value-based treatment decision making in choosing treatment options. Abstracts are due Oct. 30. Learn more about the PAN Challenge and awards.