Study compares obinutuzumab, rituximab for relapsed non-Hodgkin lymphoma patients | Researchers identify mutations related to myeloma | Brain tissue grown from human stem cells
August 20, 2015
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Study compares obinutuzumab, rituximab for relapsed non-Hodgkin lymphoma patients
Patients with relapsed CD20-positive indolent B-cell non-Hodgkin lymphoma who had previously responded to rituximab achieved a higher overall response rate with obinutuzumab than rituximab in a 175-patient midstage study reported in the Journal of Clinical Oncology. Treatment with obinutuzumab was not associated with increased progression-free survival. (8/19)
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Science & Health
Researchers identify mutations related to myeloma
A whole genome sequencing study involving 463 myeloma patients identified 15 significantly mutated genes. IRF4 and EGR1 mutations were associated with prolonged survival, while TP53, ATM, ATR and ZNFHX4 mutations were associated with reduced survival rates. The findings were reported in the Journal of Clinical Oncology. (8/19)
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Emerging Trends
Brain tissue grown from human stem cells
Ohio State University researchers have grown human brain tissue by manipulating pluripotent stem cells derived from human skin cells. The lab-grown tissue includes spinal cord cells, signaling circuitry and a retina, according to findings presented at the Military Health System Research Symposium. The Guardian (London) (8/18)
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Chip with grooves increases production of stem cell-produced heart cells, study finds
Scientists with Imperial College London have generated more cardiomyocytes from heart stem cells through the use of a silicon chip with closely spaced grooves. The findings were reported in the journal Biomaterials. Imperial College London (U.K.) (8/18)
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Preclinical study tests hydrogel, growth protein for heart muscle repair
Injection of a growth protein mixed with a biodegradable hydrogel was associated with reductions in heart damage among rats, according to a study in the journal ACS Biomaterials Science & Engineering. Rats that received the protein-hydrogel mix had at least 25% less scarring compared with rats that did not. Chemical & Engineering News (8/19)
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Industry News & Practice
Brain hemorrhage drug developer prepares initial public offering
Plans for an initial public offering have been filed by Edge Therapeutics with the goal of raising as much as $115 million. The firm's lead candidate is a reformulated treatment for ruptured aneurysms in the brain. FierceDrugDelivery (8/18)
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Grant goes to researchers working on stem cell-derived skin
Researchers with the University of Minnesota's Stem Cell Institute have been awarded a $2.4 million grant by the Richard M. Schulze Family Foundation to support their work in growing healthy skin tissue from skin-derived stem cells. Star Tribune (Minneapolis-St. Paul, Minn.) (8/18)
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AABB Members Share Knowledge and Tips in the AABB HUB
Activity in AABB's new online platform, the AABB HUB, is picking up with members exchanging views on a variety of topics within transfusion medicine, cellular therapies and patient blood management (PBM). The PBM group currently features an active thread on how members are monitoring their PBM activities. Have an opinion to share? Reply to active threads and post your questions in the HUB. Join the discussion today.
Association News
Reminder: Early discount registration for AABB Annual Meeting ends Aug. 26
Discounted registration rates for the 2015 AABB Annual Meeting -- to be held October 24-27 in Anaheim, Calif. -- will end next week. Individuals can register for the meeting online.
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