Nanotube-polymer structure promotes culturing of T cells | Protein identifies precursors of great alveolar lung cells | Gene variant linked to reduced risk of heart attack and stroke, study finds
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August 25, 2014
AABB SmartBrief
News for the transfusion medicine and cellular therapy community

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Nanotube-polymer structure promotes culturing of T cells
Yale University scientists have developed a nanotube-polymer composite structure that can multiply the production of therapeutic T cells in the lab for therapeutic use. The nanostructure includes Interleukin-2 as well as molecules that prepare the T cells to target specific cells after reinjection. The study appeared in the journal Nature Nanotechnology. (8/22)
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Science & Health
Protein identifies precursors of great alveolar lung cells
A team of scientists at Kyoto University has found a marker that can predict which precursor cells derived from induced pluripotent stem cells will develop into a specific type of lung tissue. The presence of the protein carboxypeptidase M indicates the precursors that will become great alveolar cells, according to the study in the journal Stem Cell Reports. The Mainichi (Japan) (8/22)
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Gene variant linked to reduced risk of heart attack and stroke, study finds
The risk for a heart attack is eight times lower among people who inherit a gene variant from both parents that lowers the expression of the fatty acid-binding protein FABP4, according to a study in the journal Circulation: Cardiovascular Genetics. The study also linked lower expression of the protein with reduced total cholesterol levels. Genetic Engineering & Biotechnology News (8/22)
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The Technical Manual 18th edition—NOW AVAILABLE
Revised and more relevant than ever, the 18th edition of the Technical Manual includes updated and expanded PBM content, enhanced cellular therapy chapters and inclusion of information on immunohematology reflecting both serologic and molecular aspects. For the first time, methods in SOP format are placed on a USB flash card making them customizable for easy adoption by your facility. Order your copy today!
Hot Topics
Emerging Trends
Computer vision algorithm could enable faster diagnosis of malaria
Researchers from the Institute for Molecular Medicine Finland, the University of Helsinki and Karolinska Institutet in Stockholm have designed a "man and machine" decision-support system that could diagnose malaria faster. The method, described in the journal PLOS One, involves the use of a computer vision algorithm to analyze blood cells, which are ranked according to probability of infection. A program creates a panel of images of the cells that are likely to be infected, which is used by an expert to make the final diagnosis. (India)/Asian News International (8/22)
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Experimental device detects bleeding during heart procedures
Saranas has developed a prototype for a sensor-enabled sheath that detects bleeding during cardiac procedures that involve catheterization. The device can detect bleeding near within 7 centimeters and transmits data wirelessly to a display screen. The firm is planning to conduct further testing in animals, and it is seeking 510(k) clearance from the FDA. Xconomy/Texas (8/21)
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General Registration for the AABB Annual Meeting Now Open.
Join us in Philadelphia Oct. 25-28 for the Annual Meeting. Highlights include; 125 educational sessions, 350 industry expert speakers, 550 scientific and administrative abstracts and the chance to earn up to 24.5 CE/CME credits. AABB members save $200 on the cost of registration, join today to save and enjoy the benefit of early registration. Find meeting info at Register Now.
Industry News & Practice
Antitope teams up with researchers to humanize antibody
Antitope has entered into a research agreement with University College London to humanize an anti-leucine-rich alpha-2-glycoprotein 1 antibody. Antitope will use its Composite Human Antibody technology to produce human antibodies that bind to and disrupt the function of LRG1 for use as therapies for age-related macular degeneration. Business Weekly (U.K.) (8/21)
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U.K. group offers online module on novel oral anticoagulants
The U.K.'s Medicines and Healthcare Products Regulatory Agency has developed an interactive learning module about the use of novel oral anticoagulants. The online resource is part of a series of learning guides for health care professionals from MHRA. (U.K.) (8/21)
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3D Printed Cellular Therapy Products: Regulatory Considerations
3D printing of cells is here! In this August 28 webinar presented by the AABB Center for Cellular Therapies, learn how human cells and tissues are currently and will potentially be combined with 3D printing technology. Experts will also discuss the US regulations and requirements surrounding 3D cellular printing, and how it fits into current and future regulatory frameworks.
Government & Regulatory
CMS postpones data collection for sepsis quality measure
The Centers for Medicare and Medicaid Services has announced that data collection has been suspended for the sepsis quality measure included in its inpatient prospective payment system final rule for fiscal year 2015. The measure should not be implemented yet because a committee of the National Quality Forum has called for it to be revised, the American Hospital Association has said. AHA News Now (8/22)
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ViiV Healthcare gains FDA approval for once-daily HIV drug Triumeq
The FDA has granted approval for ViiV Healthcare's triple-drug combination Triumeq for treating HIV infections in adults 18 years and older. Triumeq consists of dolutegravir, abacavir and lamivudine. The single-pill formulation taken once a day is designed to improve convenience and reduce side effects. Bloomberg (8/22), Medscape (free registration) (8/22)
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The Buzz
Join Title21 Software at the Cellular Therapy Luncheon at AABB Annual Meeting
This year's Cellular Therapy Section Business Meeting and Luncheon at AABB 2014 will be supported by Title21 Software — the all-in-one solution for the quality, inventory and laboratory process management for cell therapy and cord blood laboratories. Don't miss the presentations and discussions on the latest advancements in cellular therapy. Register now — attendance is limited.
Association News
Reminder: Advance discounted registration for Annual Meeting ends Wednesday, Aug. 27
Discounted registration rates for the 2014 AABB Annual Meeting -- to be held Oct. 25-28 in Philadelphia -- will end in two days. Individuals can register for the meeting online.
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Who's Hiring?
Position TitleCompany NameLocation
Director, Quality Assurance & Regulatory AffairsHeartland Blood CentersAurora, IL
Assistant Director, Blood Transfusion Service, Massachusetts General HospitalMassachusetts General HospitalBoston, MA
Medical Affairs DirectorBlood Systems, Inc.Scottsdale, AZ
Business Systems Analyst IIBlood Systems, Inc.Scottsdale, AZ
Click here to view more job listings.
Don't be afraid to give up the good to go for the great."
-- John D. Rockefeller,
American industrialist
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