Study ties Alzheimer's gene to neuropsychiatric symptoms after TBI | Cognitive decline may be accelerated by depression, review finds | Lung cancer more common among young US women than men
May 25, 2018
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Study ties Alzheimer's gene to neuropsychiatric symptoms after TBI
Researchers found that veterans who had a traumatic brain injury and were positive for apolipoprotein epsilon-4 genetic polymorphism, which is linked to Alzheimer's disease, were significantly more likely to develop anxiety, depression and post-traumatic stress disorder, compared with those with a normal genetic profile, but similar neuropsychiatric symptom risk was found between those with and without the APOE e4 allele who didn't have TBI. The findings in the Journal of Neurotrauma may improve understanding of the association between genetics and clinical recovery after TBI and aid in the development of better treatments, said researcher Lisa Delano-Wood.
Medscape (free registration) (5/24) 
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Clinical News & Research
Cognitive decline may be accelerated by depression, review finds
Individuals with depression were prone to greater cognitive decline in older adulthood than those who didn't have depression, researchers reported in the journal Psychological Medicine. The findings, based on a systematic review of 34 studies involving more than 71,000 people, underscore the importance of treating depression, researcher Amber John said.
Newsweek (5/24) 
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Lung cancer more common among young US women than men
A study in The New England Journal of Medicine found that diagnoses of invasive lung cancer among US adults ages 30 to 54 declined from 1995 to 2014, with men seeing a sharper decrease than women, resulting in a higher incidence of the disease in white and Hispanic women. Men were historically more likely than women to be affected by the disease, and although the reasons behind the shift are not clear, experts said men and women are prone to different forms of lung cancer, and women who quit smoking see their risk decrease more slowly than men.
HealthDay News (5/23) 
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Excess weight gain in adolescence may up bowel cancer risk in overweight boys
Overweight boys who had above-average weight gain in adolescence were 48% more likely to develop bowel cancer as adults, compared with those who had healthy weight at ages 8 and 20, according to a Swedish study to be presented at the European Congress on Obesity. However, researchers found no increased bowel cancer risk among overweight boys without excessive weight gain during puberty.
Irish Examiner/Press Association (UK) (5/23) 
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Industry Report
AcelRx's pain management drug accepted for FDA review
The FDA accepted for review AcelRx Pharmaceuticals' Dsuvia, or sufentanil sublingual tablet, 30 mcg, with a PDUFA date of Nov. 3. Dsuvia is being developed for adult patients to manage moderate-to-severe pain under medically supervised settings.
Seeking Alpha (5/24) 
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Merck's Keytruda shows positive results for squamous NSCLC
Merck announced Wednesday that recent study outcomes show that its cancer drug Keytruda increased survival times and decreased recurrence in untreated patients with squamous non-small cell lung cancer, results already seen in other forms of lung cancer. Merck plans to present expanded data at the American Society of Clinical Oncology meeting early next month.
FiercePharma (5/23) 
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News from the Field
Women underrepresented in US radiologist workforce, study says
A study in a radiology journal showed that only 23.1% of all radiologists in the US were women, compared with 46.6% of nonradiologists participating in Medicare, with the Washington, D.C., and Wyoming regions having the highest and lowest percentages of female radiologists, respectively. Researchers also found higher female representation among academic radiologists and those in states with greater female-to-male relative earnings.
Modern Medicine/Diagnostic Imaging (5/24) 
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Health Policy
House bill would postpone ACA's health insurance tax for another year
Four House lawmakers have introduced a bill that would postpone the Affordable Care Act's tax on health insurance -- already on hold in 2019 -- until 2021. AHIP praised the move, noting the suspension "will help to lower premiums for everyone, whether they get coverage through their jobs, buy their own coverage, or enroll in Medicare Advantage or Medicaid."
The Examiner (Washington, D.C.) (5/24),  Modern Healthcare (tiered subscription model) (5/24) 
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Advancing Health Care
Patient EHR enhancements may help ID possible PDMP risk areas, study shows
Enhancing patient EHRs, having graphical displays of controlled-substance prescription use and implementing maps showing distances between patients, pharmacies and prescribers could help determine the possible risk areas in prescription drug monitoring programs, according to a Pew Charitable Trusts study. Researchers also found several barriers to PDMP implementation, including time constraints associated with reviewing information in patient profiles, differences in the interpretation and application of PDMP data between states, ability to monitor the extent and appropriateness of PDMP use and high costs.
EHR Intelligence (5/23) 
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The news summaries appearing in SNMMI SmartBrief are based on original information from multiple internet sources and are produced by SmartBrief, Inc., an independent e-mail newsletter publisher. The items above are not selected or reviewed by SNMMI prior to publication. Questions and comments may be directed to SmartBrief at
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