Study evaluates hybrid multiplexing in silicon photomultiplier-based PET | Online visual test may ID dementia risk in Parkinson's | Study estimates breast, ovarian cancer risks among BRCA carriers
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June 23, 2017
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Study evaluates hybrid multiplexing in silicon photomultiplier-based PET
A hybrid multiplexing network using both resistive charge and capacitive charge divisions combined with simplified time-based readout electronics yielded good energy and time resolution as well as uniform pulse shapes across all silicon photomultiplier-based PET detectors, compared with resistive and capacitive networks alone, South Korean researchers reported in Physics in Medicine and Biology. The findings suggest the approach may be effective in "simplifying the PET readout electronics with minimal system performance degradation," said researcher Guen Bae Ko.
Medical Physics Web (registration required) (6/21) 
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Clinical News & Research
Online visual test may ID dementia risk in Parkinson's
Research presented at the International Congress of Parkinson's Disease and Movement Disorders showed how an online visual test may identify Parkinson's disease patients at highest risk of dementia. Up to half of these patients develop dementia within 10 years, and studies have found those with visual processing problems to be at higher risk.
Medscape (free registration) (6/20) 
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Study estimates breast, ovarian cancer risks among BRCA carriers
UK researchers followed nearly 10,000 cancer-free women with faulty BRCA1 and BRCA2 genes and found that the risk of breast cancer to age 80 years was 72%, peaking between ages 30 and 40, for BRCA1 carriers and 69%, peaking between ages 40 and 50, for BRCA2 carriers; meanwhile, the risk of ovarian cancer was 17% for BRCA2 carriers and 44% for BRCA1 carriers. The findings, published in JAMA, also showed the increase in breast cancer risk correlated with the number of first- and second-degree relatives with breast cancer.
Medical News Today (6/20),  Medscape (free registration) (6/20) 
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Industry Report
FDA OKs Shire's long-acting ADHD drug
Shire's Mydayis, or SHP465, has been granted approval by the FDA as a treatment for attention-deficit/hyperactivity disorder in children over 12 years old. Mydayis is formulated with the same active ingredient as Adderall XR but will last up to 16 hours.
Reuters (6/21) 
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Tessa, Parker Institute sign deal on cell therapies, immuno-oncology studies
Tessa Therapeutics has signed a multiyear agreement with the Parker Institute for Cancer Immunotherapy to develop cell therapies and immuno-oncology combination drugs using Tessa's virus-specific T cell technology. Tessa has an ongoing late-stage study of TT10 for advanced nasopharyngeal carcinoma.
BioCentury (6/19) 
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News from the Field
Opioid crackdown causes problems for chronic pain patients
Some chronic pain patients say the crackdown on opioid drug use has gone too far and they are being treated unfairly, being denied drugs they need and may have successfully used for years without problems. Jim Watkins, who has osteogenesis imperfecta, said his prescription for tramadol requires more frequent doctor visits, each with questions about his opioid use that he regards as just short of harassment.
Quad-City Times (Davenport, Iowa) (6/19) 
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Health Policy
Senate bill calls for steep cuts to Medicaid, end of mandate
Senate Republicans on Thursday released a 142-page bill, aimed at repealing and replacing the Affordable Care Act, that would make steep cuts to Medicaid and end the requirement for all Americans to have health insurance, while creating new federal tax credits to help people buy coverage. The bill, which could face opposition from conservative and moderate Republican senators along with Democrats, would allow states to drop benefits mandated by the ACA, such as maternity and mental health care.
The New York Times (free-article access for SmartBrief readers) (6/22) 
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Grants and Funding
Texas cancer, heart disease studies awarded total of $2.3M
The Max and Minnie Tomerlin Voelcker Fund has provided the University of Texas Health Science Center at San Antonio a total of over $2.3 million for a number of studies focusing on cancer and heart disease. In addition to five individual researchers who received $450,000 each via Young Investigator Awards, the center received $75,000 to study anticancer drugs.
San Antonio Express-News (tiered subscription model) (6/22) 
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Advancing Health Care
EHR-linked image database opens research opportunities
A centralized image warehouse at Mount Sinai Health Systems integrates clinical images with anonymized electronic health records for research. The system will provide opportunities for using integrated data for research, precision medicine and diagnosis in a variety of research areas, including mammography, cancer, neuro-degenerative diseases and genomics.
Health IT Analytics (6/20) 
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The news summaries appearing in SNMMI SmartBrief are based on original information from multiple internet sources and are produced by SmartBrief, Inc., an independent e-mail newsletter publisher. The items above are not selected or reviewed by SNMMI prior to publication. Questions and comments may be directed to SmartBrief at snmmi@smartbrief.com.
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