FBR stands behind UC researchers facing accusations | Zika virus vaccine validated in monkeys kills glioblastoma cells | Study in macaques suggests filoviruses linger in testes
September 19, 2018
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FBR stands behind UC researchers facing accusations
The University of California at Irvine says an animal rights group made "false statements" about animals used in research at the institution, and FBR is supporting UC Irvine as it defends its researchers against what FBR says are "subversive, ... preposterous and dangerous" accusations. "They are attacking dedicated professionals to whom all Americans owe significant medical and scientific advancements. From basic pain medications and vaccines to life-saving procedures, animal research helps both humans and animals," says FBR President Matthew R. Bailey.
Patch/Los Alamitos, Calif. (9/18) 
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Zika virus vaccine validated in monkeys kills glioblastoma cells
A live-attenuated Zika virus vaccine that protected mice and non-human primates might also kill human glioblastoma cells, according to research published in mBio. Zika virus targets fetal neural progenitor cells but is less harmful to differentiated, healthy brain cells, and the vaccine killed lab-grown glioblastoma cells as well as human glioblastoma cells transplanted into mouse brains.
United Press International (9/18),  HealthDay News (9/18) 
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Research Breakthroughs
Study in macaques suggests filoviruses linger in testes
Study in macaques suggests filoviruses linger in testes
(Sean Gallup/Getty Images)
Marburg virus persisted in the testes of crab-eating macaques, suggesting that Marburg and other filoviruses, such as Ebola, might also persist in human testes after the body clears the virus from other organs, researchers reported in Cell Host & Microbe. Marburg virus caused the breakdown of the blood-testes barrier that protects Sertoli cells, but the presence of the virus did not appear to affect sperm generation or reproductive function.
The Frederick News-Post (Md.) (9/13) 
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Cocaine overdose in mice blocked with CRISPR-edited skin patch
A skin patch of CRISPR-edited material grafted onto cocaine-addicted mice prevented them from overdosing on the drug, according to findings published in Nature Biomedical Engineering. Researchers used an augmented version of the enzyme butyrylcholinesterase, which breaks down cocaine, and expressed hope that their find could lead to a treatment for addiction.
The Scientist online (9/17) 
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Blocking a liver protein prevented obesity, NAFLD in mouse study
Blocking a liver protein prevented obesity, NAFLD in mouse study
(Pixabay)
The Argonaute 2 protein silences RNA and slows liver metabolism, impeding the organ's ability to process fat, and blocking AGO2 prevented obesity, diabetes and nonalcoholic fatty liver disease in mice fed a high-fat diet. The findings, published in Nature Communications, might have implications for treating chronic metabolic disorders in humans.
Medical News Today (9/12) 
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Souped-up arylomycin guards against Gram-negative bacteria in mice
A chemically modified version of arylomycin pierces the wall of Gram-negative bacteria and binds to an enzyme in the inner membrane of multidrug-resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii obtained from patients, researchers reported in Nature. In mice, the new molecule prevented infection by six strains of four different Gram-negative bacteria, and it showed no signs of toxicity in mammalian cells.
Science (tiered subscription model) (9/12) 
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Other News
Animal Health
Novel parvovirus explains kidney failure in lab mice
A newly identified parvovirus with genomic traits similar to viruses that affect pigs, bats and rats causes a previously unexplained renal disease in middle-aged lab mice, researchers reported in Cell. The virus could cause variation in experimental outcomes, but it could also be useful in kidney research, says lead author Ben Roediger.
The Scientist online (9/13) 
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Fat, reproductive organs good sources of stem cells for canine therapies
Fat, reproductive organs good sources of stem cells for canine therapies
(Pixabay)
Canine adipose tissue and reproductive organs might be better sources than umbilical cord blood for obtaining mesenchymal stem cells for therapeutic use in dogs, according to a recent study. Canine umbilical cord blood can be obtained only by cesarean section and yields fewer MSCs than other sources, the researchers wrote.
American Veterinarian (9/18) 
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Policy News
FDA chief unveils 2019 plan focused on antimicrobial resistance
FDA Commissioner Scott Gottlieb called for new funding mechanisms to support the battle against antimicrobial resistance, while also disclosing the agency's 2019 strategic plan that focuses on AMR. Gottlieb spoke of four crucial areas to address, including the development of products and surveillance tools for antimicrobial use and resistance, promotion of antimicrobial stewardship and support for research initiatives to discover alternative treatment approaches.
BioCentury (9/14) 
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FBR News
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The Foundation for Biomedical Research (FBR) is the nation’s oldest and largest non-profit dedicated to improving human and animal health by promoting public understanding and support for biomedical research. Our mission is to educate people about the essential role animal research plays in the quest for medical advancements, treatments and cures for both people and animals.
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