Study finds conflicting guidelines for statin use in black patients | Study: Intensive intervention improves health outcomes in diabetes | Increased CAD risk tied to genetic hyperglycemia, study finds
March 22, 2017
Cardiometabolic Health SmartBrief
Top Story
Study finds conflicting guidelines for statin use in black patients
A study in JAMA Cardiology found conflicting medical guidelines on prescribing statin drugs to black patients. Data showed about 25% of blacks who would be eligible for a cholesterol-lowering statin medication under American College of Cardiology/American Heart Association guidelines would not be under new recommendations from the US Preventive Services Task Force.
HealthDay News (3/18) 
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Science & Research
Study: Intensive intervention improves health outcomes in diabetes
A study in the Journal of Clinical Endocrinology & Metabolism showed that 50% of type 2 diabetes patients in an eight-week intensive metabolic intervention group achieved normoglycemia, compared with 3.6% of controls. Canadian researchers evaluated 83 patients and found that 21.4% of diabetes patients and 10.7% of controls in the eight-week group achieved A1C criteria for complete or partial diabetes remission 12 weeks after completing the intervention.
Physician's Briefing/HealthDay News (3/16) 
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Increased CAD risk tied to genetic hyperglycemia, study finds
Researchers found that a 1 mmol/L increase in fasting glucose was associated with a 43% increased risk of developing coronary artery disease among patients with a genetic predisposition for hyperglycemia, independent of type 2 diabetes and other CAD risk factors. The findings in Diabetes Care revealed no association between the risk for type 2 diabetes and the 12 fasting glucose-raising genetic variants.
Healio (free registration)/Endocrine Today (3/21) 
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Researchers ID factors linked to MetS development after pregnancy
A study in BMJ Open showed that an early gestational diabetes diagnosis or having signs of glucose intolerance during a prior pregnancy, as well as having high body mass index or being overweight or obese before pregnancy, were the risk factors associated with the development of metabolic syndrome during seven years of follow-up after pregnancy. Researchers evaluated 289 women from 14 maternity clinics in Finland and found no association between familial history, age or having a macrosomic baby during a prior pregnancy and MetS development after seven years.
MedPage Today (free registration) (3/20) 
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Lifestyle & Wellness
Diet, exercise program yields weight loss for NAFLD patients
An intervention that included diet, exercise and health education helped patients with and without fatty liver disease lose weight and reduce levels of alanine aminotransferase, researchers reported at the Emerging Trends in Non-Alcoholic Fatty Liver Disease conference. The study, which assessed the University of Michigan Metabolic Fitness Program, found 22.5% of patients overall and 27.3% of the NAFLD group lost 5% of their baseline weight.
Healio (free registration) (3/20) 
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Study: Low-cal diet normalizes bile acid, cholesterol
Morbidly obese women on a low-calorie diet achieved normalized hepatic bile acid and cholesterol synthesis, according to a study in the Journal of Internal Medicine. Researchers also reported the restricted-calorie diet helped normalize levels of proprotein convertase subtilisin/kexin type 9 but there was no change in fibroblast growth factor 19 or triglyceride levels.
Physician's Briefing/HealthDay News (3/20) 
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Tribal diet shows benefits of plant-based eating, exercise
A study in The Lancet found the South American Tsimane tribe has low levels of vascular aging, along with low cholesterol, blood glucose and blood pressure, and gave credit to a plant-based diet and a high level of exercise. Registered dietitians Katie Ferraro and Kristin Kirkpatrick noted the tribal diet was high in plant-based carbohydrates and that the take-away message for people in the West is to eat fewer processed foods and be more active.
Healthline (3/17) 
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Practice Trends & Technology
Improved glycemic control in diabetes seen with sacubitril/valsartan
A study presented at the American College of Cardiology's Scientific Sessions showed that type 2 diabetes patients who received sacubitril/valsartan, a combination of neprilysin inhibitor and angiotensin II receptor blocker, had a greater reduction in A1C and a nonsignificant reduction in plasma glucose, compared with those on enalapril. Researchers based their findings on a cohort of 3,778 patients with diabetes and heart failure with reduced ejection fraction. (3/18) 
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Researchers ID factors tied to diabetes therapy adherence
Type 2 diabetes patients with comorbid depression and a history of treatment noncompliance before being diagnosed with depression or who had a change in treatment plan during follow-up were at an increased risk of not adhering to their diabetes therapy, according to a study in the Journal of Diabetes and Its Complications. Canadian researchers analyzed data on 3,106 patients and found that older age, replacing their current therapy regimen or having another diabetes drug added to their current therapy, and low socioeconomic status were factors related to better adherence to diabetes therapy.
Healio (free registration)/Endocrine Today (3/17) 
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A1C improvements tied to insulin initiation in primary care, study finds
Australian researchers found that type 2 diabetes patients who received the "Stepping Up" model of care, which enhanced the practice nurses' role in leading insulin initiation and offered mentoring by a registered nurse with diabetes educator credentials, had an absolute 0.5% reduction in A1C from baseline to 12 months, compared to the control group. The findings in The BMJ revealed that 36% of those in the intervention group and 19% of control participants achieved target A1C levels. (3/20) 
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Cardiometabolic Health Congress News
CMHC Regional Conference Series 2017: Focus on Frontline Education
CMHC Regional Conference Series 2017: Focus on Frontline Education
Register for Atlanta today and save! Coupon Code: ATLANTA2017
If you are a health care practitioner actively seeking timely, tangible solutions in the field of cardiometabolic disease, this 1-day CMHC Focus on Frontline Education Regional Conference Series offers a high-quality learning experience -- coupled with the potential for networking with like-minded providers and professionals. Earn up to 8 CME/CE credits!
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Novel Therapies for LDL-C Lowering in the Fight Against Residual ASCVD Risk: Digital Monograph
This digital monograph, featuring video snippets and key slides from the 2015 CMHC Annual meeting features experts discussing the latest information on novel LDL lowering therapies, including PCSK9 inhibitors. Clinical case examples are presented to provide tactics for treatment intensification and how best to integrate new therapies into management plans for high-risk patients. Learn more.
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Learn more about CMHC:
Home page | Online Education program menu home page | CMHC Boston 2017
CMHC 2017 Regional Conference Series | About CMHC page
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