Higher fat levels raise A1C risks in adults without diabetes | Study links health outcomes to glycemic control in diabetes after PCI | Study: Microvascular complications in diabetes are not tied to glucose variation
Higher levels of total fat and trunk fat in adults without diabetes were linked to a greater risk of having an A1C in the prediabetes range, according to a study in the Journal of the Endocrine Society. Researchers said the association was not as consistent for people who already had diabetes.
A South Korean study in Circulation: Cardiovascular Interventions showed that type 2 diabetes patients who maintained good blood glucose control experienced improved long-term health outcomes seven years after undergoing percutaneous cardiac intervention, compared with those who didn't manage their blood glucose levels. Researchers evaluated 980 diabetes patients and found an association between lower A1C levels after PCI and a reduced rate of major adverse cardiac and cerebrovascular events.
A study in Diabetes Care showed no association between within-day glucose variability and the development and progression of diabetic nephropathy, retinopathy and cardiovascular autonomic neuropathy, after adjusting for mean blood glucose levels in type 1 diabetes patients. Researchers analyzed data from the Diabetes Control and Complications Trial and found that microalbuminuria was significantly associated with the longitudinal mean M-value after adjusting for the mean blood glucose and using the Holm procedure to correct multiple tests.
Women who were overweight or obese and struggled to exercise improved their blood glucose levels 45 minutes after being treated with electroacupuncture, according to a study in the FASEB Journal. Swedish researchers found that electroacupuncture activates the sympathetic and partly the parasympathetic nervous systems, which increases whole-body glucose uptake.
Research in the Annals of Internal Medicine found people with a normal BMI but central obesity had a 22% higher risk of early death, and those with a BMI in the obesity range had a 13% increased risk, compared with people who stored fat in other areas of the body. Data showed having central obesity increased the risk of heart-related death by 25% among people with a normal BMI, 26% for those who were overweight and 56% for people with a BMI in the obese range.
Physical activity may be a risk reduction factor for heart failure in adults, including for those who are obese, researchers said. Their study in the journal JACC: Heart Failure showed that compared with people who followed recommended exercise guidelines, those who did not exercise had a 39% higher risk of heart damage.
Obese postmenopausal women with a sedentary lifestyle who adopted a calorie-restricted diet for six months saw improved body composition and fat distribution, researchers reported in the journal Menopause. The study found 12 of 20 women with metabolic syndrome at baseline no longer had the condition but six out of 53 women who did not have metabolic syndrome at the start developed it by the end of the intervention.
A study published in The BMJ found riding a bike to work, compared with a sedentary commute, was associated with a 46% reduced risk of cardiovascular disease, a 45% lower likelihood of cancer and a 41% lower chance of premature death over five years. Researchers said walking to work was linked to a 27% lower risk of CVD and a 36% lower likelihood of dying from it.
Patients with poorly controlled type 2 diabetes reduced their A1C levels by 0.9% on average after taking vildagliptin along with metformin over 180 days, with more than 50% of patients experiencing a 0.7% reduction in A1C levels, according to a study in the Journal of Diabetes. Israeli researchers used a cohort of 345 adults and also found that 38% of patients lost at least 2.2 pounds in body weight.
Danish researchers found patients with type 2 diabetes who achieved A1C levels of less than 6.5% after six months of metformin initiation had the lowest risk for cardiovascular events or death, while those who had an A1C of at least 8% had the highest risk. The findings in Diabetes Care, based on 24,752 adults with a mean age of 62.5, showed that large A1C reductions among those with a baseline A1C of more than 9% were associated with the greatest outcome risk reductions.
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This spotlight article explores obesity as a multifactorial, recurring disorder, with key genetic and environmental drivers. The article will also challenge practitioners to acknowledge obesity as a serious disease, and help overcome common stigmas and barriers to treatment and maintenance. Learn more.