Researchers ID gluten-degrading enzyme that may help treat celiac disease | Study: TE may be useful in detecting subclinical cirrhosis in HBV patients | Researchers develop system to detect drug resistance in HCV
July 1, 2015
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Clinical Updates
Researchers ID gluten-degrading enzyme that may help treat celiac disease
An enzyme called pseudolysin, which comes from the Pseudomonas aeruginosa bacterium, degrades gluten in an acidic environment and might be useful in treating celiac disease, according to a study published in The American Journal of Gastroenterology. Gluten-degrading activity at low pH levels would allow digestion during gastric passage, before immune destruction begins, the researchers wrote. Read the abstract. Healio (free registration)/Gastroenterology (6/30)
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Study: TE may be useful in detecting subclinical cirrhosis in HBV patients
Transient elastography identified patients infected with the hepatitis B virus who were at high risk of developing hepatocellular carcinoma but who had no evidence of cirrhosis, researchers in South Korea said. Additional studies are needed to confirm that using TE in HCC surveillance is cost-effective and provides benefits, the researchers noted. Healio (free registration) (6/29)
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Researchers develop system to detect drug resistance in HCV
A system that can screen for the drug-resistant NS5A-Y93H mutation in hepatitis C patients has been developed by Hiroshima University researchers. A study showed the system had a success rate of 98.9% in detecting drug resistance when used with 702 serum samples acquired from HCV patients with genotype 1b infection. HCPLive (6/30)
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Legal & Regulatory
States may form regional insurance exchanges
States need not set up their own health insurance exchange for their residents to qualify for federal tax credits, and some that did might decide to default to the federally run exchange. Others may set up regional insurance marketplaces with neighboring states. Another option may be for states to partner with the federal government and use for enrollment but run certain aspects of the marketplace. The Wall Street Journal (tiered subscription model) (6/26)
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Practice News
Gastroenterologist suggests ways for experienced docs to boost skills
Experienced gastroenterologists can improve their skills by interacting with younger colleagues who have advanced endoscopic training, reading journals regularly, going to national and regional meetings, and participating in teaching and clinical research, writes Dr. Larry Good, FACG, CEO of Compassionate Care Center of New York. "Preparing lectures, responding to questions and expanding one's horizons by participating in or initiating clinical research projects creates an environment of critical thinking and expanding horizons," he writes. (6/26)
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Business & Market Trends
Acute HCV cases underreported, study finds
Less than 1% of acute hepatitis C virus infection cases that occurred in Massachusetts between 2001 and 2011 were reported to the CDC because of minimal symptoms and fragmented care, a study found. Only one of 149 cases reported to the Massachusetts Department of Public Health met all the CDC criteria of a reportable case, but if the department had access to all available data, 33 other cases would have been considered reportable, the analysis showed. Healio (free registration)/HCV Next (6/29)
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Report: Specialty-drug prices likely to drive up medical inflation
The FDA is approving more specialty drugs than traditional drugs, and high prices on specialty drugs to treat hepatitis C, cancer and high cholesterol are likely to have an effect on medical costs and inflation, according to a new PricewaterhouseCoopers report. (6/29)
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Patient's Perspective
Experts call for patients to have better access to their own data
Doctor talking with a patient.
(Adam Berry/Getty Images)
Americans increasingly want access to their own medical data, but even with digitization of records, it has been easier for regulatory offices, researchers and others to gain access to patient data than it's been for the people themselves. Improved access to medical records shows promise for cutting medical errors, improving patient engagement and cutting wasteful spending. The Wall Street Journal (tiered subscription model) (6/29)
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ACG News
Esophageal Disorders
Hear experts identify optimal candidates for surgical or endoscopic treatment of GERD; describe the diagnosis and management of EoE, including long term treatment of the disease; and discuss the current approach to treating Barrett's esophagus, including endoscopic therapies, when you attend the 2015 ACG Midwest Regional Postgraduate Course, Aug. 22-23, at the InterContinental Kansas City at the Plaza in Kansas City, Mo. The course will also feature presentations on IBD, hepatitis B and C, functional bowel disorders, GI oncology, colon polyps and cancer, and more. Hands-on sessions will also be offered. The InterContinental Kansas City at the Plaza is located in the Country Club Plaza, 15 blocks of restaurants and shops. Learn more about the course and register today.
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Challenging cases in HCV therapy
Hear expert Neeral L. Shah, M.D., explain the latest treatment options for challenging patients with hepatitis C when you attend the ACG/VGS/ODSGNA Regional Postgraduate Course, Sept. 12 and 13 at the Williamsburg Lodge in Williamsburg, Va. Other topics to be presented include chronic pancreatitis, refractory esophageal strictures, complex polypectomy techniques, IBD, and more. In addition, a special nurse's session will be offered, Esophageal Disorders: A Difficult Diagnosis to Swallow, along with hands-on demonstrations for nurses. Learn more and register today.
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nun, artist and educator
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