A study in the American Journal of Respiratory and Critical Care Medicine found women who were exposed to cleaning agents at home or work had a greater decline in lung function and a higher prevalence of asthma over time. Researchers evaluated 20 years of data for 6,235 participants in the European Community Respiratory Health Survey and found lung function decline linked to cleaning agents exposure was comparable to almost 20 pack-years of smoking.
An analysis of more than 50 million pregnancy-related hospitalizations showed women with heart failure had higher risks of adverse maternal outcomes during the antepartum, delivery and postpartum periods, according to a study in Circulation: Heart Failure. Researchers said women at high risk should be identified during hospitalization, and surveillance programs should be developed before discharge.
Adults who had a childhood heart defect were over two times more likely to develop early-onset dementia than those who did not have a heart defect, and the risk escalated with the severity of the heart condition, researchers reported in the journal Circulation. Adult survivors of childhood heart defects also were 30% more likely to develop dementia after age 65.
A study in The American Journal of Gastroenterology found nonceliac gluten sensitivity is not commonly seen in children. Among children with a history of functional chronic gastrointestinal symptoms, 96.7% did not have symptoms that correlated with gluten ingestion. Read the abstract.
CDC researchers reported that the batch of flu vaccine distributed this year cut risk of serious illness by 36% overall, 59% among children ages 6 months to 8 years and 33% among adults ages 18 to 49. The findings in the agency's Morbidity and Mortality Weekly Report also showed this year's vaccine cut risk of serious cases of H3N2 -- the dominant strain of the season -- by 25%; risk was reduced 67% for H1N1 and 42% for influenza B strains.
Children with later-onset spinal muscular atrophy who underwent intrathecal nusinersen administration had a 4-point increase in mean Hammersmith Functional Motor Scale-Expanded scores from baseline to month 15, compared with a 1.9-point decline among those who received placebo, Italian researchers reported in The New England Journal of Medicine. The findings also showed that 57% of those in nusinersen group had at least 3 points increase in HFMSE scores, compared with 26% of those in the control group.
The number of deaths among diabetes patients with an estimated glomerular filtration rate of less than 60 mL/min/1.73 m2 and an albumin-to-creatinine ratio of less than 30mg/g increased from 35 to 51 deaths per 1,000 person-years from 1988 to 1994 and 2003 to 2006, according to a study in Diabetes Care. Researchers evaluated data from the National Health and Nutrition Examination Surveys 1988 to 2006 and found an increase in mortality rates for adults with an eGFR of less than 60 mL/min/1.73 m2 and an ACR of less than 30 mg/g, but a decline in mortality rates among those with an ACR of at least 30 mg/g.
Researchers found that the rate of sudden unexpected infant deaths in the US dropped from 154.6 per 100,000 live births in 1990 to 92.4 per 100,000 in 2015, with a 44.6% decline from 1990 to 1998 but only a 7% decrease from 1999 to 2015. Sudden infant death syndrome prevalence declined by 35.8% while the rate accidental suffocation and strangulation in bed rose by 183.8% during the same period, according to the study in Pediatrics.
FDA Commissioner Scott Gottlieb said a national e-prescribing system is needed for controlled substances. Legislation -- the Every Prescription Conveyed Securely Act -- introduced by Rep. Katherine Clark, D-Mass., could help reduce prescription drug abuse and improve efforts to reduce the risk of certain prescription drugs, Gottlieb said.
HHS Secretary Alex Azar told lawmakers during a House committee hearing that HHS remains committed to ensuring affordable access to health care and keeping Medicare solvent by driving out fraud, waste and abuse. Azar said his priorities include shifting Medicare toward a more value-based, outcome-based program; reducing prescription drug costs; and expanding telehealth services.