A screening method for preeclampsia that includes measurement of biomarkers in addition to the mother's risk factors outperforms a standard method, which relies on medical history and maternal characteristics. "It is now time to revise the professional guidelines and to move away from using a checklist-based method for screening," said study co-author Liona Poon.
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The US Preventive Services Task Force issued updated recommendations urging men ages 55 to 69 to talk with doctors about prostate-specific antigen testing and then decide for themselves whether to pursue the screening. The update reflects increased use of "active surveillance" rather than aggressive treatment, mitigating the possible harms of widespread screening.
A Health Affairs study found there are 75,000 genetic tests on the market and about 10 are added each day. The study found that spending was highest on prenatal tests, with testing for hereditary cancer coming in second, from 2014 to 2016.
High levels of malaria parasite Plasmodium vivax were found in the bone marrow of 14 monkeys that died of malaria infections. The research suggests the need for "new diagnostic tools to estimate parasite burden in the marrow from markers in the bloodstream, as direct bone marrow diagnosis is not feasible," said Matthias Marti, lead author of the study in the journal mBio.
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Lawmakers should enact the Diagnostic Accuracy and Innovation Act, which would modernize regulation of laboratory-developed tests, in vitro diagnostics and other clinical laboratory diagnostics, according to a letter sent by a consortium of laboratories, manufacturers and advocacy groups to Congress. "As stakeholders we stand ready to continue the work necessary to finalize a consensus diagnostic reform package this year," they wrote.
Accountable care organizations participating in Track 1 of the Medicare Shared Savings Program, which has no financial penalty for missing goals, have struggled to contain costs and, as a group, increased Medicare spending, while those that have taken on downside financial risk reduced federal spending. Many ACOs that failed to reach targets and instead owe money are likely to leave the program and might not have the resources to participate in any value-based care models.
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CareDx and Illumina have reached a licensing deal on Illumina's next-generation sequencing transplant clinical application products. CareDx will be the exclusive global distributor of Illumina's TruSight HLA v1 and v2 product lines and associated software, which it plans to use for diagnostic testing for bone marrow and solid organ transplantation.
A definitive licensing deal was completed by PAVmed for Case Western Reserve University's EsoCheck technology, a combination of cell sampling device and DNA biomarker test designed for Barrett's esophagus detection. PAVmed has formed a subsidiary called Lucid Diagnostics, which will have the exclusive worldwide rights to the development and commercialization of the technology and all derivatives.