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Biomarkers for Alzheimer's disease
Young adults at genetic risk for autosomal dominant Alzheimer's disease have functional and structural MRI findings and Cerebrospinal fluid (CSF) and plasma biomarker findings consistent with A?1?42 overproduction. Although the extent to which the underlying brain changes are either neurodegenerative or developmental remain to be determined, this study shows the earliest known biomarker changes in cognitively normal people at genetic risk for autosomal dominant Alzheimer's disease. (Free registration required)  Lancet Neurology, The (11/2012)