Weekly E-Mail newsletter For physicians in Internal Medicine, Cardiology, Geriatrics, Women's Health, and Adolescent Medicine News from hundreds of top industry sources It's what clinicians need to know It's FREE!       Privacy Information       SmartBrief and AJM will not rent, sell, or trade your e-mail address to any external entities -- ever. Click here to read our Privacy Policy.       About SmartBrief About The American Journal of Medicine, published by Elsevier About Elsevier Visit other Elsevier Health Science publications     Send AJMPlus story to a colleague. * Your Name * Your E-mail * Friend's E-mail Separate multiple addresses with commas.   Personal Message * Indicates required fields Terms and Conditions: You must submit valid e-mail addresses only. Use of e-mail addresses is subject to the terms of SmartBrief's privacy policy. Here's the story you're sending: Trisomy 18 and trisomy 21 detection Chromosome-selective sequencing of maternal cell?free DNA (cfDNA) and fetal-fraction-optimized data analysis provide effective first-trimester detection of fetal trisomies 21 and 18.  American Journal of Obstetrics & Gynecology (4/2012)